Blueallele Corporation

Cellectis

University of Minnesota

Nicholas J Baltes

Song Luo

Daniel F Voytas

Javier Gil Humanes

Methods and compositions for modifying the coding sequence of endogenous genes using rare-cutting endonucleases and transposases. The methods and compositions described herein can be used to modify the coding sequence of endogenous genes.

Methods for targeted insertion of DNA in genes

Materials and methods are provided for making plants (e.g.,varieties) with increased levels of dietary fiber, such as by making TALE nuclease-induced mutations in alleles encoding starch branching enzyme IIa (SBEIIa) and starch branching enzyme IIb (SBEIIb).

Engineering wheat with increased dietary fiber

Materials and methods for creating plants (e.g., alfalfa lines) with reduced lignin content and composition are provided herein, as are plants, plant parts, and plant cells generated by the methods provided herein.

Alfalfa with reduced lignin composition

Systems and methods for gene targeting in plants, including systems and methods that include the use of geminiviruses and customizable endonucleases.

Gene targeting in plants using DNA viruses

Materials and methods are provided for making plants with altered levels of amino acids, particularly by making controlled frameshift mutations in genes that are highly expressed in plant leaves or plant seeds.

Growing community of inventors

Maple Grove, MN, United States of America

Nicholas J Baltes