Schering Corporation

Schering-plough Corporation

Nicholas I Carruthers

Pauline C Ting

Cheryl A Alaimo

Neng-Yang Shih

Gregory A Reichard

Ashit K Ganguly

John J Piwinski

Robert G Aslanian

Kevin D McCormick

Bandarpalle B Shankar

Martin Steinman

Pietro Mangiaracina

James J Kaminski

Michael P Kirkup

Esther Babad

Shing-Chun C Wong

James M Spitler

Andrew Lupo, Jr

Brian J Lavey

Daniel M Solomon

Wing C Tom

Steven K White

Compounds within the genus represented by the structural formula I ##STR1## or a pharmaceutically acceptable salt thereof, wherein: T is substituted phenyl or substituted pyridyl; ##STR2## R.sup.4 is methyl or ethyl; and Z is substituted piperidinyl.

Substituted oximes as neurokinin antagonists

Compound represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: a is 0, 1, 2 or3;

Substituted oximes, hydrazones and olefins as neurokinin antagonists

Compound represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: a is 0, 1, 2 or 3;

Disclosed are compounds of Formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I, methods for inhibiting tumor necrosis factor-.alpha. and methods for treating septic shock, inflammation, or allergic disease.

Tricyclic derivatives, compositions and methods of use

The invention relates to compounds of the formula ##STR1## wherein X, i, j, n, n', A, A', R.sub.2, R.sub.3, and U are as described herein. The compounds of the invention are NK.sub.1 or NK.sub.2 or NK.sub.3 receptor antagonists and as such are useful in the treatment of diseases such as asthma.

Piperidine derivatives as neurokinin antagonists

Pentacyclic antihistamines

There is disclosed an improved process for preparing albuterol which comprises reacting a 5-(haloacetyl)-2-hydroxybenzaldehyde with 1,1-dimethylethanamine in an organic solvent and in an inert atmosphere to form 5-[[(1,1-dimethylethyl)amino]acetyl]- 2-hydroxybenzaldehyde and reducing the carbonyl functions to the corresponding hydroxy groups to form albuterol.

Method for the preparation of .alpha..sup.1

There is disclosed an improved process for preparing albuterol which comprises reacting a 5-(haloacetyl)-2-hydroxybenzaldehyde with 1,1-dimethylethanamine in an organic solvent and in an inert atmosphere to form 5-[[(1,1-dimethylethyl)amino]acetyl]-2-hydroxybenzaldehyde and reducing the carbonyl functions to the corresponding hydroxy groups to form albuterol.

Intermediates in the preparation of alpha1(((1,1-dimethylethyl) amino)

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North Plainfield, NJ, United States of America

Nicholas I Carruthers