Janssen Pharmaceutica Nv

Ortho-mcneil Pharmaceutical Corp.

Other

Johnson & Johnson Pharmaceutical Research & Development, LLC

Ortho-mcneil Pharmaceuticlas, Inc.

Janssen Pharmaceuticals, Inc.

Nicholas I Carruthers

Chandravadan R Shah

Curt A Dvorak

Xiaobing Li

Jill A Jablonowski

Timothy W Lovenberg

Ronald L Wolin

Wenying Chai

Dale A Rudolph

J Guy Breitenbucher

Devin M Swanson

Richard Apodaca

Laura C McAtee

Brock T Shireman

Wei Xiao

Annette K Kwok

Victoria Wong

Vi T Tran

James Patrick Edwards

Michael Anthony Letavic

Kiev S Ly

Cheryl A Grice

Neelakandha S Mani

Jianmei Wei

John M Keith

Barbara A Pio

Xiaohu Deng

Hui Cai

Mark Seierstad

Jimmy T Liang

Ann J Barbier

Leslie A Gomez

Victoria D Wong

Todd Kevin Jones

Gregor James MacDonald

Jennifer Diane Venable

Scott L Dax

William V Murray

Mark Andrew Youngman

Daniel J Pippel

Haripada Khatuya

Akinola Soyode-Johnson

Emily M Stocking

Brett D Allison

Lars Karlsson

Victor K Phuong

Robin L Thurmond

Lana K Young

Siquan Sun

Steven W Sutton

Pascal Bonaventure

Jennifer M B Miller

Michael Bogenstaetter

Jennifer D Kreisberg

Siguan Sun

Barbara Pio

Certain biphenyic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.

Serotonin receptor modulators

Certain biphenyl compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.

Modulators of serotonin receptors

Certain 2-aminopyrimidine compounds of formula (I) are serotonin receptor modulators useful in the treatment of diseases mediated by serotonin receptors. 

2-aminopyrimidine compounds as serotonin receptor modulators

The biphenyic compounds of formula (I) are serotonin modulators useful in the treatment of serotonin-mediated diseases. 

Modulators of serotonin receptor

Certain hexahydro-pyrrolo-isoquinoline compounds are histamine Hreceptor and serotonin transporter modulators useful in the treatment of histamine Hreceptor- and serotonin-mediated diseases.

Hexahydro-pyrrolo-isoquinoline compounds

Certain substituted pyrrolidine amide compounds are histamine Hreceptor modulators useful in the treatment of histamine Hreceptor-mediated diseases.

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The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; sleep/wake disorders; cardiovascular disease; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility. The compounds of the present invention are of the formula where Ring T is a heterocycloalkyl ring selected from the group consisting of: 

Substituted piperazines and piperidines as modulators of the neuropeptide Y2 receptor

Certain cyclopropyl amines are histamine Hmodulators useful in the treatment of histamine Hreceptor mediated diseases.

Certain isoxazole compounds are histamine Hmodulators useful in the treatment of histamine Hreceptor mediated diseases.

Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.

Fused heterocyclic compounds

Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine Hreceptor, including allergic rhinitis.

Heterocyclic compounds

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Poway, CA, United States of America

Nicholas I Carruthers