Tufts University

Nicholas H Dodman

Louis Shuster

NMDA receptor antagonists can be used in methods of treatment, for reducing the frequency of stereotypic behaviors in animals and for reducing the frequency of analogous compulsive behaviors in humans, for example, those that have been said to be a manifestation of, or related to, obsessive-compulsive disorder. Of particular interest are the (&plus;) enantiomers of opioid receptor binding compounds, which can reduce the frequency of the behaviors, while having no effects from binding at the opioid receptor.

Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors

A veterinary method for clinically modifying the behavior of a household pet dog exhibiting a recognized type of canine affective aggression behavior is provided. The veterinary behavior modification method administers at least one compound selected from the group consisting of R enantiomers, S enantiomers, or a racemic mixture of selective serotonic reuptake inhibitors or their active metabolites to the dog upon one or multiple occasions; and the administration of these compounds will modify clinically the canine affective aggression behavior of the household dog permanently or for an indefinite period of time. This veterinary behavior modification method can be usefully employed as an adjunct to conditioning approaches presently employed and will avoid the need for euthanasia in extreme behavioral circumstances.

Veterinary method for clinically modifying the behavior of dogs

A veterinary method for clinically modifying the behavior of a household pet dog exhibiting a recognized type of canine affective aggression behavior is provided. The veterinary behavior modification method administers at least one preferential serotonin reuptake inhibitor compound to the dog upon one or multiple occasions; and the administration of these compounds will modify clinically the canine affective aggression behavior of the household dog permanently or for an indefinite period of time. This veterinary behavior modification method can be usefully employed as an adjunct to conditioning approaches presently employed and will avoid the need for euthanasia in extreme behavioral circumstances.

A veterinary method for clinically modifying the behavior of a household pet dog exhibiting a recognized type of canine affective aggression behavior is provided. The veterinary behavior modification method administers at least one selective serotonin reuptake inhibitor compound to the dog upon one or multiple occasions; and the administration of these compounds will modify clinically the canine affective aggression behavior of the household dog permanently or for an indefinite period of time. This veterinary behavior modification method can be usefully employed as an adjunct to conditioning approaches presently employed and will avoid the need for euthanasia in extreme behavioral circumstances.

An improved animal litter preparation is provided for attracting a household domesticated animal and for absorbing liquids and liquid-containing waste released by the attracted animal. The litter preparation comprises a plurality of preformed and nontoxic liquid absorbing masses of solid matter each comprised of an absorbent substance, at least one releaser pheromone compound which is a biological attractant for the animal, and at least one blending agent.

Pheromone containing animal litter preparations

The present invention provides a veterinary treatment method for animals suffering from a high arousal state. The treatment employs a class of pharmacologically active compounds having a pyrimidinyl-piperazine ring structure of which the most preferred member is buspirone. These compounds are administered to a variety of different domestic animals and household pets exhibiting behavioral problems which often are refractory to other modes of treatment.

Veterinary method for treating inappropriate elimination of urine in

A method of treating animals exhibiting stereotypic behavior by administering a therapeutically effective amount of a narcotic antagonist is disclosed. The stereotypic behaviors include cribbing, wind-sucking, head bobbing, head skaking, head nodding, pacing, pawing and stall-walking. A kit for treating this stereotypic behavior is also disclosed.

Growing community of inventors

Grafton, MA, United States of America

Nicholas H Dodman