University of Florida Research Foundation, Incorporated

Nicholas G Paciaroni

Hendrik Luesch

Robert William Huigens, Iii

The present disclosure provides compounds of Formulae (I-A), (II'), (III-A), (IV&#x2032;), and (V-A), wherein the compounds are derived from or based on yohimbine. The provided compounds may be useful in treating or preventing a disease (e.g., proliferative disease, cancers, inflammatory diseases, autoimmune diseases, and infectious diseases) in a subject in need thereof. The present disclosure provides methods of preparing compounds of Formulae (I-A), (II&#x2032;), (III-A), (IV&#x2032;), and (V-A). Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein. 

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Gainesville, FL, United States of America

Nicholas G Paciaroni