Astrazeneca Ab

Astra Zeneca U.k. Limited

Astra Pharmaceuticals Limited

Pulmagen Therapeutics (synergy) Limited

Pulmagen Therapeutics Limited

Nicholas David Kindon

Stephen Thom

Premji Meghani

David R Cheshire

Bryan Glyn Roberts

Andrew Baxter

Lilian Alcaraz

Thomas McInally

Anthony Howard Ingall

Stephen Brough

Michael Stocks

Peter A Cage

Barry John Teobald

Antonio Mete

Andrew Bailey

Timothy Johnson

Garry Pairaudeau

Nicholas Tomkinson

Stephen J Brough

Andrew J G Baxter

John Steele

Richard James Bull

Andrew James Robbins

Michael John Stocks

Andrew Stuart Lister

The present invention relates to spirocyclic amide derivatives of the formula I, pharmaceutically acceptable salts thereof, a process for their preparation, pharmaceutical compositions containing them, and their use in therapy.

Compounds

Spirocyclic amide derivatives of formula I whereinArCHCHNH&#x2014; represents a &#x3b2;-adrenoceptor binding group, processes for their preparation, pharmaceutical compositions containing them, a process for preparing such pharmaceutical compositions, their use in therapy, and intermediates for use in their preparation.

Compounds-801

Compounds&#x2014;801

The invention provides N-pyrazinyl-phenyl-sulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma. 

N-pyrazinyl-phenylsulphonamides and their use in the treatment of chemokine mediated diseases

The invention provides N-pyrazinyl-thienylsulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma 

The invention provides compounds of general formulawherein R, m, Q, T, n, R, R, V, W, X and Rare as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

The invention provides piperidine compounds of general formula (I) in which A, B, X, Y, Z, R, R and R are as defined in the specification, their use as medicaments, compositions containing them and processes for their for their preparation.

P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular disease

Piperazine derivatives as modulators of chemokine receptor activity

The invention provides compounds of general formula (I) wherein: R represents optionally substituted, C -C alkyl or optionally substituted 3- to 10-membered saturated or unsaturated ring system comprising up to two ring carbon atoms that form carbonyl groups and comprising up to 4 ring heteroatoms independently selected from nitrogen, oxygen and sulfur; m is 0-1; Q represents OCH , C -C alkylene or C -C alkenylene; T represents C(O)NH, or when m is 0, T may additionally represent a bond or NH, or when m is 1 and Q represents C -C alkylene, T may additionally represent NH; n is 1-4; each R and R independently represents H or C -C alkyl; V represents N, and W represents N or CH; X represents O, C(O), CH(OH), SO , NH or N(C -C alkyl), provided that when W represents N, then X represents either C(O) or SO and when W represents CH, then X is other than SO ; R represents optionally substituted phenyl; R and R each independently represent H, C -C alkyl or hydroxyC -C alkyl, or R and R together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocyclic ring; R and R each independently represent H or C -C alkyl; and R represents OH or &mdash;NR R ; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Uracil compounds as P2-purinoreceptor 7-transmembrane G-protein coupled receptor antagonists

The invention relates to new pharmaceutically active compounds which are are P2-purinoceptor 7-transmembrane (TM) G-protein coupled receptor antagonists, compositions containing them and processes for their preparation.

Pyrimidin derivatives

2,4-Dithi(oxo)-pyrimidin-5-yl compounds bearing a tricyclic substituent

Phosphate compounds and their use as medicaments

Growing community of inventors

Leicestershire, United Kingdom

Nicholas David Kindon