Pfizer Corporation

Array Biopharma Inc.

Nicholas Charles Lazzara

Ellen Ruth Laird

Bradley Jon Newhouse

Spencer Phillip Pajk

John Joseph Gaudino

Mark Laurence Boys

Erik James Hicken

Rachel Zoe Rosen

Bryan Daniel Ellis

Russell Andrew Shelp

This invention relates to compounds of Formula (I): and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein A, L, R, R, R, R, and n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts, and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

HER2 mutation inhibitors

This invention relates to compounds of Formula (I): and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein L, L, R, R, Rand n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors

Growing community of inventors

Denver, CO, United States of America

Nicholas Charles Lazzara