Boston University

Angio-medical Corp.

Other

Nicholas Catsimpoolas

Robert S Sinn

Robert McCluer

Ahmad R Kamarei

Michael I Klibaner

James Evans

Ann L Griffith

Sandor Szabo

Haralambos P Gavras

Joseph Lane

Takashi Mise

Harry S Goldsmith

Christian C Haudenschild

Meryl S Rubin

Ganglioside mixtures and/or lipid mixtures e.g. from brain and omentum, are found to be effective to treat peptic ulcers.

Composition and method for treatment of gastric and duodenal ulcers and

Factors isolated from omental extracts are used to promote bone healing, for example in fractures in mammals.

Method for healing bone damage

Lipid material or ganglioside from mammalian sources e.g. bovine and porcine brain or omentum is used to treat peptic ulcers.

Method for the treatment of gastric ulcer

A method for enhancing angiogenesis and/or blood vascular perfusion in mammals by administering a pharmacologically effective amount of specific angiogenically active non-ionic, anionic, cationic and zwitterionic amphiphilic compounds. An angiogenically effective amount of the angiogenically active compound digitonin is in the range of at least 1.25 microgram to at least 200 microgram of digitonin. The range including enhancement of vascular perfusion is up to 50 mg of digitonin.

Angiogenic and blood perfusion inducing properties of amphiphilic

A method for causing or increasing angiogenesis is described. The method involves administering to a subject, such as a human being in need of angiogenesis an angiogenically effective amount of an angiogenically effective, pharmaceutically acceptable oligosaccharide or mixture of oligosaccharides.

Method for provoking angiogenesis by administration of angiogenically

Compositions which contain lipid containing molecules possessing angiogenic activity are disclosed. The lipid containing molecules have been found in mammalian tissue, particularly the omentum, of various animals. Additionally, known lipids, such as gangliosides, are unexpectedly found to possess angiogenic activity. A method for obtaining the omentum-derived lipids, and for use of these and known lipids, are disclosed as well.

Method for enhancing angiogenesis with lipid containing molecules

36 Lipid extracts and lipid fractions from mammalian omenta containing mostly lipids are used cosmetically for skin conditions, skin care and cosmetic products which products have skin softening applications without skin irritation, greasiness or mutagenic effect. These materials with and without ganglioside are used for skin conditions such as keratosis, white spots and the like.

Lipids from omentum and methods for cosmetic use

Angiogenesis healing factors residing in omentum-derived lipid fractions with or without gangliosides or their synthetic equivalents can be used to treat myocardial ischemic conditions including but not limited to myocardial infarction, angina, as well as in heart transplant, vascular grafts, and re-opened vessels leading to improved vascularization, perfusion, collagenization and organization of said lesions; the involved and adjacent tissues.

Method for treatment of angina and myocardial infarctions with omental

Lipid containing molecules and compositions, including gangliosides and omental tissue extracts had previously been found to be effective in increasing angiogenesis. It has now been found that these same materials cause increased localized perfusion in mammals. A method for providing increased perfusion, using these compositions, is presented herein.

Increased vascular perfusion following administration of lipids

Omental lipid fractions accelerate wound healing especially as to epithelialization in mammals.

Method for enhancement of healing of epithelial wounds in mammals

Plasmin inhibitory substances have been found in mammalian omental extracts. The substances all contain lipid components. In addition, related commercially available lipid containing molecules, such as mono-, di-, and trisialogangliosides are found to possess unexpected plasmin inhibitory properties. This suggests methods of therapy for diseases and conditions where blood clotting and fibrin degradation products, are implicated.

Lipids with plasmin inhibitory properties

Compositions containing ganglioside molecules with enhanced angiogenic

A novel angiogenic composition obtained from the omentum is provided which acts as a potent and effective factor for blood perfusion enhancement and for the development of new blood vessels in an organized structural network in living tissues. The angiogenic composition is a lipid or lipids, essentially protein-free as extracted from the omentum using organic solvents. This composition can then be injected to target to a site where new blood vessel formation, or blood perfusion enhancement is required. This material can be used to heal various damaged tissues including bone and heart.

Angiogenic factor methods of extraction and method for producing

Plasmin inhibitory substances have been found in mammalian omental extracts. The substances all contain lipid components. In addition, related commercially available lipid containing molecules, such as mono-, di-, and trisialogangliosides are found to fossess unexpected plasmin inhibitory properties. This suggests methods of therapy for diseases and conditions where blood clotting and fibrin degradation products, are implicated.

Seizures are inhibited or prevented and tranquilizing effect induced by administering riboflavin or a riboflavin analog, alone or in combination with a conventional anticonvulsant or tranquilizer to enhance its effect.

Growing community of inventors

Newton Centre, MA, United States of America

Nicholas Catsimpoolas