Janssen Pharmaceutica Nv

Pharmacia & Upjohn Company

Nicholas Bernard Johnson

James Henshilwood

Gerard Andrew Potter

Bradley D Hewitt

Jane Marie Paul

Mark Joseph Burk

David Andrew Chaplin

A process for the asymmetric transformation of a racemic compound of formula (I) wherein R is H or a alkyl group having up to 20 carbon atoms, R is H, or an alkyl, aryl, alkaryl or aralkyl group having up to 20 carbon atoms, and X is H, a halogen atom, tert-butyl, or any other removable substituent, comprises reaction of racemic compound (I) with an enantiomerically-enriched acid HY*, wherein Y* is a chiral group, to form a diastereomeric salt of compound (I) having Y* as a counterion. The salt obtained can then be reduced to give enantiomerically-enriched galanthamine, or a derivative thereof.

Optical resolution of narwedine-type compounds

The subject invention concerns a process for the preparation of a compound of formula (2), which comprises phenolic oxidation of a compound of formula (1)

Oxidative process and products thereof

The present invention is a process for the preparation of a compound of the formula:

Process for asymmetric hydrogenation

Oxidative process for preparing narwedine derivatives

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Cambridge, United Kingdom

Nicholas Bernard Johnson