Synthetic Genomics, Inc.

Exxonmobil Research and Engineering Company

Viridos, Inc.

Nicholas Bauman

Imad Ajjawi

Eric R Moellering

John Verruto

Moena Aqui

Andrew Schultz

Saheed Imam

Roberto Spreafico

Kathleen Kwok

Shaun Bailey

Fedor I Kuzminov

Randor R Radakovits

Jennifer Nominati

Robert Christopher Brown

Rekha Seshadri

Srividya Akella

Stanley Bower

Jennie Lau Kit

Vincent A Bielinski

Kate Lyons Boyd

Paul G Roessler

Amanda R Edwards

Disclosed herein are mutant photosynthetic microorganisms having an attenuated SGI1 gene. The mutants have reduced chlorophyll and increased productivity with respect to wild type cells. Also disclosed are methods of using such mutants for producing biomass or bioproducts, and methods of screening for such mutants.

High productivity algal mutants having reduced photosynthetic antenna

Disclosed herein are mutant photosynthetic microorgnaisms having an attenuated SGI1 gene. The mutants have reduced chlorophyll and increased productivity with respect to wild type cells. Also disclosed are methods of using such mutants for producing biomass or bioproducts, and methods of screening for such mutants.

The application provides recombinant microorganisms with increased productivity with respect to control or wildtype microorganisms. The recombinant microorganisms can include a non-native gene encoding a SKP1 polypeptide or a CHORD-derived polypeptide. Increased productivity can be increased biomass or lipid productivity. These recombinant microorganisms can be used to produce products of interest.

Microorganisms engineered for increased productivity

The present application provides novel regulatory elements including promoter sequences from microorganisms. The application further discloses DNA constructs containing these novel regulatory elements, and recombinant microorganisms comprising these regulatory elements. Methods of modifying, producing, and using the regulatory elements are also disclosed. The regulatory elements and transformation methods disclosed herein are particularly suited for use inand other microalgae.

Compositions and methods for expressing genes in algae

The present invention provides for the improved production of fatty acid products in a recombinant microorganism or host cell engineered to express a non-native gene encoding a thioesterase and a non-native gene encoding a lysophosphatidic acid acyltransferase (LPAAT), in which the LPAAT is overexpressed in the recombinant microorganism compared to an otherwise identical microorganism that does not include the non-native LPAAT gene. The invention also provides methods of producing fatty acid products using such recombinant microorganisms.

Recombinant microorganisms comprising thioesterase and lysophosphatidic acid acyltransferase genes for fatty acid production

The present invention relates to the regulation of a toxin and/or antitoxin genes in a genetically engineered microorganism, such as cyanobacterial or eukaryotic algal strains, in particular for preventing unintentional and/or uncontrolled spread of the microorganisms. The present invention also includes methods of controlling the growth and/or survival of the engineered microorganism

Regulation of toxin and antitoxin genes for biological containment

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San Diego, CA, United States of America

Nicholas Bauman