Alchemia Limited

Dr. Reddy's Laboratories, Incorporated

Nicholas B Drinnan

Michael Leo West

Tracie E Ramsdale

Joachim Seifert

Latika Singh

Wim F Meutermans

Gerald B Tometzki

George Adamson

Giovanni Abbenante

Bernd Becker

Giang Thanh Le

Matthias Grathwohl

Premraj Rajaratnam

Preparation and use of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides useful for the preparation of synthetic heparinoids.

Synthetic heparin pentasaccharides

Preparation and use of synthetic trisaccharides useful for the preparation of synthetic heparinoids.

Synthetic heparin trisaccharides

Preparation and use of synthetic disaccharides useful for the preparation of synthetic heparinoids.

Synthetic heparin disaccharides

Preparation of synthetic monosaccharides, for use in the preparation of synthetic heparinoids.

Synthetic heparin monosaccharides

Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.

Disaccharides for drug discovery

Preparation of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides for use in the preparation of synthetic heparinoids.

Growing community of inventors

Highgate Hill, Australia

Nicholas B Drinnan