Pfizer Corporation

Nicholas A Saccomano

Robert A Volkmann

Fredric J Vinick

Douglas Phillips

Paul R Kelbaugh

Steven D Heck

Deane M Nason, Ii

Mary E Kelly

Robert T Ronau

Calcium channel blocking polypeptides from filistata hibernalis

Pore forming peptides from Geolycosa riogrande

Calcium channel blocking polypeptides from Heteropoda venatoria

Calcium channel blocking polypeptide from agelenopsis aperta and

Antidepressant agents having the formula ##STR1## wherein R.sup.1 is a polycycloalkyl group; R.sup.2 is methyl or ethyl, X is O or NH; and Y comprises a 5- or 6-membered heterocyclic ring having one or two nitrogens; or fused bicyclic heterocyclic rings having a total of three nitrogen atoms, one in each ring and one angular nitrogen.

Calcium independent camp phosphodiesterase inhibitor antidepressant

An optically active compound selected from the group consisting of a compound having the absolute stereochemical formula ##STR1## and a compound having the absolute stereochemical formula ##STR2## and intermediates thereof.

Endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents

Enzymatic resolution of endo-bicyclo[2.2.1]heptan-2-ol and derived

This invention relates to certain polyamines and polypeptides found to be present in the venom of the Agelenopsis aperta spider. The polyamines of this invention and the salts thereof antagonize excitatory amino acid neurotransmitters, which neurotransmitters affect cells of various organisms and are useful in antagonizing said neurotransmitters, per se, in the treatment of excitatory amino acid neurotransmitter mediated diseases and conditions and in the control of invertebrate pests. The polypeptides of this invention and one of said polyamines and the salts thereof block calcium channels in cells of various organisms and are useful in blocking said calcium channels in cells, per se, in the treatment of calcium channel mediated diseases and conditions and in the control of invertebrate pests. This invention also relates to compositions comprising said polyamines, polypeptides and salts thereof.

Polyamines and polypeptides useful as antagonists of excitatory amino

Calcium independent C amp phosphodiesterase inhibitor antidepressant

Compounds having the formula R-(CH.sub.2).sub.m -CO-R' wherein R is ferrocene, a 5 to 7 member azacyclic system or an 8 to 11 member azabicyclic system, having 1 or 2 nitrogen atoms, or any such system substituted with one or more of F, Cl, Br, OH, C1 to C4 alkyl, C1 to C4 alkoxy, CF.sub.3, phenyl, amino, C1 to C4 alkylamino and di(C1 to C4 alkyl)amino; m is 0 or 1; and R' is

Synthetic heteroaryl polyamines as excitatory amino acid

Antidepressant agents having the formula ##STR1## wherein R.sup.1 is a polycycloalkyl group; R.sup.2 is methyl or ethyl, X is O; and Y comprises a 5-membered heterocyclic ring having one or two nitrogens.

Aryl substituted nitrogen heterocyclic antidepressants

This invention relates to a polypeptide found to be present in the venom of the Agelenopsis aperta spider and to polypeptides having substantially the same amino acid sequence and substantially the same activity as said polypeptide. The polypeptides of this invention and the salts thereof block calcium channels in cells of various organisms and are useful in blocking said calcium channels in cells, per se; in the treatment of calcium channel mediated diseases and conditions; and in the control of invertebrate pests. This invention also relates to compositions comprising said polypeptides and salts thereof.

Polypeptides useful as blockers of calcium channels

This invention relates to certain polyamines found to be present in the venom of the Agelenopsis aperta spider. The polyamines of this invention and the salts thereof antagonize excitatory amino acid neurotransmitters, which neurotransmitters affect cells of various organisms, and are useful in antagonizing said neurotransmitters, per se, in the treatment of excitatory amino acid neurotransmitter mediated diseases and conditions and in the control of invertebrate pests. This invention also relates to compositions comprising said polyamines and salts thereof.

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Ledyard, CT, United States of America

Nicholas A Saccomano