Abbott Laboratories Corporation

Tap Holdings, LLC

Tap Pharmaceuticals, Inc.

Nicholas A Mort

Fortuna Haviv

Jonathan Greer

Rolf E Swenson

Charles J Nichols

John T Randolph

Daryl Richard Sauer

Christopher R Dalton

Timothy D Fitzpatrick

Steven Armen Boyd

Milan Bruncko

Andrew O Stewart

Meena V Patel

Gui-Dong Zhu

Pramila A Bhatia

David M Stout

David L Arendsen

Indrani W Gunawardana

Catherine M McCarty

Michael A Staeger

Michele A Kaminski

Jennifer C Freeman

Lisa Marie Frey

Bradley W Crawford

Kraig Lartey

Kevin R Condroski

Philip Waid

Cell adhesion-inhibiting antiinflammatory compounds

Disclosed are 3'-N-desmethyl-3'-N-susbstituted-6-O-methyl-11-deoxy-11,12-cyclic carbamate erythrolide A derivatives which are antagonists of luteinizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.

Macrolide LHRH antagonists

Disclosed are 3',3'-N-bisdesmethyl-3',3'-N-bis-substituted-6-O-methyl-11-deoxy-11,12-cyc lic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.

3',3-N-bis-substituted macrolide LHRH antagonists

Disclosed are 3'-N-desmethyl-3'-N-substituted-6-O-methyl-11-deoxy-11,12-cyclic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.

6-position modified decapeptide LHRH antagonists

Peptides possessing LHRH antagonistic activity, and useful for the controlling the release of LHRH in mammals are decapeptide analogues of LHRH having a lactam group at the N-terminus of the formula ##STR1## where n is 1, 2, or 3 and R.sup.1 is selected from the group consisting of hydrogen, benzyl, 4-chlorobenzyl, 2-methylnaphth-1-yl, 1-methylnaphth-2-yl, and quinolin-3-ylmethyl.

LHRH antagonists having lactam groups at the N-terminus

Decapaptide and undecapaptides substituted on the N-terminal nitrogen atom by acyl groups which include furo-2-yl, isonicotinyl, nicotinyl, 2-, 3-, and 4-quinolinecarbonyl, shikimyl, dihydroshikimyl, and tetrahydrofur-2-oyl are potent antagonists of LHRH and are useful for suppressing the levels of sex hormones in mammals.

N-terminus modified analogs of LHRH

Decapaptides substituted on the N-terminal nitrogen atom by acyl groups are potent antagonists of LHRH and are useful for suppressing the levels of sex hormones in mammals.

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Waukegan, IL, United States of America

Nicholas A Mort