Gnosis Spa

Niccolo Miraglia

Davide Bianchi

Ermanno Valoti

Paola Bazza

Marco Valetti

Daniele Giovannone

Simona Daly

Immacolata Busiello

Marco Berna

Federica Colzani

Francesca Bollini

Cesare Ponzone

Ignazio Castagliuolo

Nicola Angelo Maria Volpi

Paola Brun

Antonella Trentin

Mauro Rossini

Marco Agostinetto

Antonio Trilli

Disclosed is a low molecular weight (1000-5000 daltons) chondroitin sulfate (CS) produced by chemical sulfation of a non-sulfated chondroitin backbone (K4 capsular polysaccharide) obtained with biotechnology techniques. The CS described is substantially monosulfated, mainly at the 6-position, with very little sulfation at the 4-position, and with a mono/disulfated disaccharide ratio and charge density similar to those of natural CS. Said biotechnological chondroitin sulfate (CS) is useful in the treatment and prevention of osteoarthritis and in acute and chronic inflammatory processes.

Low polydispersity, low molecular weight biotechnological chondroitin sulfate with anti-inflammatory and antiarthritis activity and use thereof in the prevention of osteoarthritis

Disclosed are solid forms of menaquinol and processes for obtaining them by chemical or enzymatic reduction of menaquinone. Said solid forms possess high stability to oxidation which allows effective use of menaquinol in the most common formulations wherein vitamin K2 is used.

Solid forms of menaquinols

The present invention discloses a process for the production of chondroitin sulphate with an average molecular weight (Mw) of 10-30 kDa by chemical sulphation starting from an unsulphated chondroitin backbone, obtained in turn by acid hydrolysis of capsular polysaccharide K4 made directly fromstrain O5:K4:H4, or directly produced from a genetically modified strain of. Sulphation of the N-acetyl-D-galactosamine residue at position 4 or 6 takes place simultaneously in the same polysaccharide chain, simulating the sulphation pattern observed in natural chondroitin sulphate, unlike the sulphation obtained with the synthesis methods described to date.

Biotechnological sulphated chondroitin sulphate at position 4 or 6 on the same polysaccharide chain, and process for the preparation thereof

Disclosed is a composition containingvarand the enzyme superoxide dismutase.

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Desio, Italy

Niccolo Miraglia