The United States of America, as Represented by the Secretary, Department of Health and Human Services

Niamh X Cawley

Bruce J Baum

Yoke Peng Loh

Christopher R Snell

Saravana Radha Krishna Murthy

Yoke-peng Loh

Terence K Lee

The invention provides a method of determining the prognosis of cancer in a subject. The method comprises (a) obtaining a sample from the subject, (b) analyzing the sample for the expression level of a carboxypeptidase E (CPE) splice variant, and (c) correlating the expression level in the sample with the prognosis of cancer in the subject. The invention further provides a method of diagnosing cancer, methods of treatment, kits for detecting mRNA expression of a CPE-&#x394;N, and inhibitors of CPE-&#x394;N and compositions thereof.

Method for predicting and detecting tumor metastasis

The invention provides a nucleic acid molecule encoding a growth hormone (GH) in which the RSP sorting signal has been mutated, such that the GH can be constitutively secreted by the nonregulated secretory pathway (NRSP) in a mammalian cell. The invention also provides a nucleic acid molecule encoding a GH in which the three-dimensional conformation of the RSP sorting signal has been altered such that the GH can be constitutively secreted by the NRSP in a mammalian cell.

Nucleic acids encoding growth hormone with a modified RSP sorting signal

The invention provides a growth hormone (GH) in which amino acids within the regulated secretory pathway (RSP) sorting signal have been mutated as well as a GH in which the three-dimensional conformation of the RSP sorting signal has been altered, and a composition comprising an effective amount of such a GH in an excipient.

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Bethesda, MD, United States of America

Niamh X Cawley