Advanced Cardiovascular Systems, Inc.

Abbott Cardiovascular Systems, Inc.

Schneider (usa) Inc.

Boston Scientific Scimed, Inc.

Other

Boston Scientific Corporation

Abbott Vascular, Inc.

Scimed Life Systems, Inc.

Xoft, Inc.

Schneider Gmbh

Ni Ding

Stephen D Pacetti

Michael N Helmus

Wouter Erik Roorda

Syed F A Hossainy

Eugene T Michal

Fritz Hostettler

Michael R Forman

David Rhum

Syed Faiyaz Ahmed Hossainy

Fuh-Wei Tang

Yunbing Wang

Lothar W Kleiner

Charles David Claude

James Oberhauser

Murthy V Simhambhatla

Xiao Ma

Thierry Glauser

Yiwen Tang

Paul M Consigny

Evgenia Mandrusov

Manish Gada

Srinivasan Sridharan

Ashok A Shah

Jennifer E Raeder-Devens

Shaw Ling Hsu

Bethany Steichen

Tuyethoa Thi Trinh

Leonard Pinchuk

Chad Joseph Abunassar

Laveille Kao Voss

Diem Uyen Ta

Marlene C Schwarz

Yeung Siu Yu

Rommel Lumauig

Deborra Sanders Millare

Kelly Justin McCrystle

Joel Harrington

Kalpana Kamath

Senthil Kumar Eswaran

Jill A McCoy

Cameron K Kerrigan

Ian J Clark

W Scott Andrus

Christopher J Buchko

Marika Kamberi

Syed Faiyez Ahmed Hossainy

Sepideh Hashemi

Boyd V Knott

Gene Michal

Michael Robert Forman

Thomas David Esbeck

Darius Francescatti

Qing Lin

Erika Danielle Anderson-Bolden

Andrew F McNiven

Derek Mortisen

Xinmin Xu

Marc Culkin

James P Oberhauser

Methods are disclosed including thermally processing a scaffold to increase the radial strength of the scaffold when the scaffold is deployed from a crimped state to a deployed state such as a nominal deployment diameter. The thermal processing may further maintain or increase the expansion capability of the scaffold when expanded beyond the nominal diameter.

Thermal processing of polymer scaffolds

Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.

Controlling moisture in and plasticization of bioresorbable polymer for melt processing

An amorphous PDLLA stent coating for drug delivery is disclosed.

PDLLA stent coating

Methods of reducing crimping damage to polymer and drug coating on a scaffold are disclosed. The methods include physically aging a coating including a coating polymer and drug mixture on a scaffold in a manner that takes into account the differing kinetics of aging, that is, the different temperature dependence of the aging rate of the polymer and drug.

Methods for increasing coating strength to improve scaffold crimping yield

Method are disclosed for local and systemic administration HDL, recombinant HDL or HDLm for the prevention, treatment, or amelioration of a vascular disorder, disease or occlusion such as restenosis or vulnerable plaque.

High-density lipoprotein coated medical devices and methods of treatment using the devices

A composition for loading into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The composition may comprise a therapeutic agent, and a chelator, a precipitation agent, or a combination thereof. Medical devices, such as stents, with a structural element defined by a lumen and at least one opening to access the lumen, filled with the compositions are also described.

Hollow stent filled with a therapeutic agent formulation

Disclosed herein are drug delivery medical devices. A polymer coating for a medical device is provided which comprises a minimum amount of a drug bonded to the polymer in the coating.

Drug delivery scaffold or stent with a novolimus and lactide based coating such that novolimus has a minimum amount of bonding to the coating

A method of providing an antioxidant to a medical device and a kit are described.

Methods of providing antioxidants to a drug containing product

Methods of making polymeric devices, such as stents, using solvent based processes. More particularly, methods of making bioabsorbable stents.

Solvent method for forming a polymer scaffolding

It is provided herein modified polylactide (PLA) polymers comprising biocompatibile functional group(s) on the polymers and methods of making and using the modified PLA polymers.

Modified polylactide polymers

Methods of incorporating an antioxidant into a medical device including a polymer are described, and methods of packaging medical devices.

Kits including implantable medical devices and antioxidants

A polymer of siloxanes as flexibility monomers and strength monomers is provided. It is also provided a polymer blend that contains a polymer formed of siloxane monomers and strength monomers and another biocompatible polymer. The biocompatible polymer or polymer blend described herein and optionally a bioactive agent can form a coating on an implantable device such as a drug-delivery stent. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

Polymers containing siloxane monomers

Methods are disclosed for conditioning a polymeric stent after sterilization, and/or after crimping and before packaging, such that the properties of the polymeric stent fall within a narrower range of values. The stent is exposed to a controlled temperature at or above ambient for a period of time after radiation sterilization and/or after crimping and before sterilization. As a result, the polymeric stent properties, particularly radial strength and number-average molecular weight of the polymer of the polymeric stent, fall within a narrower range.

Post electron beam conditioning of polymeric medical devices

A polymer comprising phospholipid moieties and a biocompatible polymer backbone, a composition comprising the polymer and optionally a bioactive agent, an implantable devices such as a drug eluting stent comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.

Phosphoryl choline coating compositions

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San Jose, CA, United States of America

Ni Ding