Forest Laboratories Holdings Limited

Merck Serono S. A.

Forest Laboratories Holding Limited

Nhut Diep

Gian-Luca Araldi

Andreas Goutopoulos

Matthias Schwarz

Henry Yu

Srinivasa R Karra

Benny C Askew

Yuriy B Kalyan

Matthew Ronsheim

Melanie Simone Ronsheim

Shao Hong Zhou

Alexander Bischoff

Methods for the synthesis of disubstituted aminouracils and xanthine and/or xanthine-related compounds are provided.

Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds

The invention provides novel arylamino N-heteroaryl MEK inhibitors of Formula (I): Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed is the treatment of a hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.

Arylamino N-heteraryl compounds as MEK inhibitors

The present invention relates to pyridoazepine derivatives that act as 5-HT ligands, e.g., 5-HTC. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

Pyridoazepine derivatives

Arylamino N-heteroaryl compounds as MEK inhibitors

The present invention relates to compounds of formula I, II, III or IV: 

Substituted imidazo(1,2-A)pyrimidines and imidazo(1,2-A) pyridines as cannabinoid receptor ligands

Methods for the synthesis of heterocyclic compounds including N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide and pharmaceutically acceptable salts thereof.

Synthesis of heterocyclic compounds

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Hauppauge, NY, United States of America

Nhut Diep