Salix Pharmaceuticals, Inc.

University System of Maryland

Inkine Pharmaceutical Company, Inc.

Ngoc Do

Martin Rose

Stephen Skiendzielewski

Min Michael He

Larry Augsburger

Cheng Der Tony Yu

This invention relates to novel colonic purgative compositions in a solid dosage form, comprising at least one purgative and at least one soluble, or soluble, nonfermentable binder, such as polyethylene glycol. Further, this invention relates to methods of using the colonic purgative compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time improving the quality of bowel cleansing. The formulations and methods of this invention are particularly useful to cleanse the bowel prior to diagnostic and surgical procedures and can also be employed in lower dosages as a laxative to promote elimination and/or to relieve constipation.

Colonic purgative composition with soluble binding agent

Novel methods for making dosages form comprising a cushioning component. The methods of the present invention provides dosage forms which can be compressed to form compressed dosage forms that are substantially uniform in composition and robust and exhibit reduced friability. The invention also relates to methods for making fast-disintegrating dosage forms.

Methods for making pharmaceutical dosage forms containing active cushioning components

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Bel Air, MD, United States of America

Ngoc Do