Biochem Pharma Inc.

Shire Biochem, Inc.

Vertex Pharmaceuticals (canada) Incorporated

Viro Chem Pharma, Inc.

Iaf Biochem International, Inc.

Nghe Nguyen-Ba

Laval Chan Chun Kong

Bernard R Belleau

Sanjoy Kumar Das

Tarek S Mansour

Oswy Z Pereira

Haolun Jin

Bernard Belleau, Deceased

Boulos Zacharie

Thumkunta Jagadeeswar Reddy

Gervais Dionne

Allan H Tse

Dilip M Dixit

Colleen A Evans

William L Brown

Miguel Quimpere

Laval Chan Kong

Carl Poisson

Liliane Halab

Melanie Proulx

Benoit Bachand

Sophie Levesque

Mohammad Arshad Siddiqui

Arshad Siddiqui

Zhang Ming-Qiang

Bettina Hamelin

Constantin G Yannopoulos

Rabindra Rej

Wuyi Wang

Jean Bedard

Mingqiang Zhang

Livio Brasili

Pierrette Belleau

Pierette Belleau, Executrix Of Estate

Pierette Belleau

Thunkunta Jagadeeswar Reddy

Ming Qiang Zhang

Mélanie Proulx

Ming-Qiang Zhang

Compounds represented by formula: Wherein X, Y and Z are as defined herein, pharmaceutically acceptable salts thereof, and related compounds, are suitable for use in treating or preventing a Flaviviridae viral infection in a host.

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Compounds represented by formula: wherein X, Y and Z are as defined herein, pharmaceutically acceptable salts thereof, and related compounds, are suitable for use in treating or preventing a Flaviviridae viral infection in a host.

Compounds and methods for the treatment or prevention of flavivirus infections

The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.

The acetaldehyde compounds, 2-thiobenzoylacetaldehyde diethylacetal, 2-benzoyloxyacetaldehyde bis(2-methoxyethyl)acetal, 2-hydroxyacetaldehyde bis( 2-methoxyethyl)acetal, 2-thiobenzoylacetaldehyde bis(2-methoxy-ethyl)acetal, and 2-thioacetaldehyde bis(2-methoxyethyl)acetal, are useful as intermediates in the synthesis of substituted 1,3-oxathiolanes and substituted 1,3-dioxolanes.

Acetaldehyde acetal compounds, their synthesis, and uses thereof

Use of a compound of formula (I) or a pharmaceutically acceptable derivative thereof in the manufacture of a medicament for the treatment of hepatitis B is disclosed.

Use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis B

The present invention provides novel compounds represented by formula I:or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.

Substituted 1,3-oxathiolanes, such as cis- and trans-2-ethoxycarbonyl-5-hydroxy-1,3-oxathiolane and cis- and trans-2-ethoxycarbonyl-5-acetoxy-1,3-oxathiolane, are suitable as intermediates for the production of substituted 1,3-oxathiolanes nucleoside analogs having antiviral properties.

Substituted 1,3-oxathiolanes

Processes for preparing substituted 1, 3-oxathiolanes with antiviral properties

The present invention is concerned with novel &lsqb;1,8&rsqb; naphthyridine derivatives useful for the inhibition of the hepatitis virus, more specifically the hepatitis C virus.

&lsqb;1,8&rsqb; naphthyridine derivatives having antiviral activity

Antiviral nucleoside analogues

Antiviral phosphonate nucleotides

The current invention is down to (&plus;) an (&minus;) enantiomers, as well as racemic mixtures of nucleoside analogs, wherein the carbohydrate portion of the analog is a dioxolane moiety and the nucleobase moiety is N -carbocyclic-alkylamino-substituted-2-amino-purine moiety attached via its N position to the dioxolane moiety. The compounds are useful for treating viral infections such as HBV and HIV infections, alone or in combination with other therapeutic agents.

Antiviral methods using &lsqb;1,8&rsqb;naphthyridine derivatives

Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives:

Process for preparing antiviral 2-phosponate nucleotide analogs

Growing community of inventors

La Prairie, Canada

Nghe Nguyen-Ba