Sour Pliva

Pliva Farmaceutska Kemijska, Prehrambena I Kozmeticka Industrija S.p.o.

Nevenka Lopotar

Slobodan Djokic

Zlatko Vajtner

Hrvoje Krnjevic

Gabrijela Kobrehel

Bozidar Suskovic

Amalija Narandja

Olga Carevic

Lidija Kolacny-Babic

The invention relates to the use of complexes and chelates resp., of antitics with bivalent and/or trivalent metals in antiulcer drugs, to new complexes and chelates resp., of antibiotics with bivalent and/or trivalent metals and to processes for the obtaining thereof.

Complexes and chelates of azithromycin with bivalent and/or trivalent

Derivatives of tylosin and 10,11,12,13-tetrahydro tylosin of the general formula ##STR1## wherein R stands for CHO, CH.sub.2 OH, CH.dbd.NOH or CH(OCH.sub.3).sub.2,

Derivatives of tylosin and 10,11,12,13-tetrahydro tylosin and their use

New 2:1 complexes of N-methyl-11-aza-10-deoxo-10-dihydroerythromycin A or 11-aza-10-deoxo-10-dihydroerythromycin A with bivalent metals chosen form the group comprising Cu.sup.+2, Zn.sup.+2, Co.sup.+2, Ni.sup.+2 and Ca.sup.+2, a process for their manufacture and their use in the manufacture of antibiotically active pharmaceuticals. New 2:1 complexes of N-methyl-11-aza-10-deoxo-10-dihydroerythromycin A or 11-aza-10-deoxo-10-dihydroerythromycin A with bivalent metals chosen from the group comprising Cu.sup.+2, Zn.sup.+2, Co.sup.+2, Ni.sup.+2 and Ca.sup.+2 are made by reacting N-methyl-11-aza-10-deoxo-10-dihydroerythromycin A or 11-aza-10-deoxo-10-dihydroerythromycin A in its free base form or in its water-soluble salt form with salts of said bivalent metals. The compounds possess antibiotic activity.

Metal complexes of N-methyl-11-aza-10-deoxo-10-dihydro-erythromycin A or

10-dihydro-10-deoxo-11-azaerythronolide A compounds and pharmaceutically acceptable acid addition salts of said compounds; methods and intermediates for the manufacture thereof; their use as antiinflammatory agents and processes for their preparation.

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Zagreb, Yugoslavia

Nevenka Lopotar