Yeda Research and Develpment & Co. Ltd

Netta Sela-Paswell

Irit Sagi

Raanan Margalit

Tamar Danon

Moran Grossman

A method of generating an antibody which inhibits a metalloenzyme is disclosed. The method comprises immunizing a subject with: Antibodies generated by this method are also disclosed as well as uses thereof.

Methods of generating antibodies to metalloenzymes

An antibody is disclosed which comprises an antigen recognition region which comprises six CDR amino acid sequences selected from the group consisting of SEQ ID NOs: 4-15. Uses thereof are also disclosed.

Antibodies that inhibit metalloproteins

The present application relates to antibodies which recognize [2(2-aminoethylcarbomoyl)-ethoxymethyl]-tris-[2-N-(3-imidazol-1-yl-propyl))-ethoxymethyl]methane, a hapten molecule which closely mimics the local structure and conformation of the reactive zinc site in matrix metalloproteinases. An antibody is disclosed which comprises an antigen recognition region which comprises six CDR amino acid sequences selected from the group consisting of SEQ ID NOs: 4-15. Uses thereof are also disclosed.

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Rehovot, Israel

Netta Sela-Paswell