Edwards Lifesciences Corporation

Edwards Lifesciences Pvt, Inc.

Other

Trueleaf Medical Ltd.

Netanel Benichou

Tamir S Levi

Son V Nguyen

Bella Felsen

Benjamin Spenser

Ziv Yohanan

Elena Sherman

Assaf Bash

Stanton J Rowe

Nikolay Gurovich

David Maimon

Ron Sharoni

Larisa Dadonkina

David Alon

Oded Meiri

Ilia Hariton

Diana Nguyen-Thien-Nhon

Itai Pelled

Rajesh A Khanna

Yaacov Nitzan

Avraham Zakai

Henry Bourang

Yaron Keidar

Michael Bukin

Larry L Wood

George Bakis

Sean Chow

Lauren R Freschauf

Emil Karapetian

Alexander J Siegel

William Charles Brunnett

Mark M Dehdashtian

Cristobal R Hernandez

Gregory I Bak-Boychuk

Christopher J Olson

Nikolai Gurovich

Alison S Curtis

Rajesh Khanna

Maria Charles Vija Stanislaus

Charles Stanislaus

Nik Gurovich

Alex Siegel

Amit Tubishevitz

Larry Wood

Llia Haritou

Som Nguyen

Diana Nguyen-Thien-Nh

Llia Hariton

This application relates to methods, systems, and apparatus for replacing native heart valves with prosthetic heart valves and treating valvular insufficiency. In a representative embodiment, a support frame configured to be implanted in a heart valve comprises a main body formed by formed by a plurality of inner members forming an inner clover and a plurality of outer members forming an outer clover. The support frame can include gaps located between inner members of the plurality of inner members and outer members of the plurality of outer members. The inner clover can be radially inside the outer clover, and the outer clover can have larger dimensions than the inner clover. The support frames herein can be radially expandable and collapsible.

Valvular insufficiency repair device and method

An implantable prosthetic valve includes a frame and a leaflet structure positioned within the frame. The frame has a plurality of angled struts arranged to form a plurality of circumferentially extending rows of closed cells, including an uppermost row of closed cells defining an outflow end of the frame. The leaflet structure includes a plurality of leaflets, each having two opposing commissure portions and a lower edge portion coupled to the frame. Each commissure portion is paired with an adjacent commissure portion of an adjacent leaflet to form a commissure of the leaflet structure. The frame has a plurality of commissure support portions supporting respective commissures. The commissure support portions are positioned axially along the frame entirely within the uppermost row of closed cells. The commissure support portions are circumferentially spaced apart from each other by a plurality of closed cells of the uppermost row of closed cells.

Leaflet attachment frame for prosthetic valve

Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.

Prosthetic heart valve

A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.

Prosthetic heart valve having improved commissure supports

This application relates to methods, systems, and apparatus for replacing native heart valves with prosthetic heart valves and treating valvular insufficiency. In some implementations, a heart valve leaflet clipping mechanism includes a delivery apparatus and clipping arms. The clipping arms are coupled to the delivery apparatus. The clipping arms are movable between an open position and a closed position. The two clipping arms are biased to the closed position. The delivery apparatus is configured to hold the clipping arms in the open position. The delivery apparatus is configured to allow the clipping arms to move to the closed position to engage native heart valve leaflet tissue.

Stent structure for an implantable prosthetic heart valve

A delivery assembly includes a prosthetic device, a catheter shaft, a release wire, a first line, and a second line. The prosthetic device has a first arm and a second arm. The release wire extends through the catheter shaft. The first line includes a first loop. The first line extends from the catheter shaft, through the first arm of the prosthetic device, and to the release wire, where the release wire extends through the first loop. The second line includes a second loop. The second line extends from the catheter shaft, through the second arm of the prosthetic device, and to the release wire, where the release wire extends through the second loop.

Prosthetic heart valve and delivery apparatus

An implantable prosthetic valve has an upper frame section and a lower frame section. The upper frame section has a plurality of struts and a first leaflet receiving surface at a lower portion of the upper frame section. The lower frame section has a second leaflet receiving surface at an upper portion of the lower frame section. An edge of a flexible leaflet is disposed between the first and second leaflet receiving surfaces to attach the leaflet to the upper and lower frame sections.

A prosthetic heart valve comprises a radially collapsible and expandable annular frame and a leaflet structure comprising three leaflets. Each leaflet has an upper edge portion, a curved lower edge portion and two side flaps, wherein each side flap is connected to an adjacent side flap of another leaflet to form commissures of the leaflet structure, with each commissure being attached to the frame. An annular inner sleeve comprises three U-shaped portions positioned along the curved lower edge portions of the leaflets. An annular outer sleeve extends around are outer surface of the frame, wherein the outer sleeve is made of pericardium. The frame is made of Nitinol and the prosthetic valve can be radially crimped to a radially collapsed configuration inside a sheath for delivery into a patient's body and self-expand to a radially expanded configuration when released from the sheath inside the patient's body.

Low profile transcatheter heart valve

An assembly for replacement of a native aortic heart valve includes a radially collapsible prosthetic heart valve and a delivery apparatus. The prosthetic heart valve includes an annular frame with attachment posts, wherein each of the posts has an axial post portion and a transverse post portion having a greater circumferential dimension than the axial post portion. The delivery apparatus includes an inner shaft with a valve connection portion for releasably coupling to the attachment posts and an outer shaft having a sheath for maintaining the prosthetic heart valve in a radially compressed state. Rotation of a control knob on a handle causes the sheath to retract for uncovering a portion of the prosthetic heart valve. Further rotation of the control knob allows the posts to decouple from the delivery apparatus such that the prosthetic heart valve self-expands to a fully expanded state.

Prosthetic heart valves are described. Prosthetic heart valves can include radially expandable and compressible inner and outer metal frames. The inner frame can be disposed within a lumen of the outer frame and can be coupled to the outer frame. An outflow end of the inner frame can be coupled to and/or located at an outflow end of the outer frame. An end portion of the inner frame can be spaced radially inwardly from an inner surface of the outer frame, such that a radial gap exists between the inner surface of the outer frame and an outer surface of the inner frame. Prosthetic heart valves can further include a plurality of leaflets disposed within and supported by the inner frame, such as by commissure posts of the inner frame.

Prosthetic heart valve having an inner frame and an outer frame

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D.N. Hof HaCarmel, Israel

Netanel Benichou