Technion Research & Development Foundation Ltd

Hadasit Medical Research Services and Development Ltd.

Compugen Ltd. Corporation

Rappaport Family Institute for Research in the Medical Sciences

Hadasit Medical Research Services and Development Company

Neta Ilan

Israel Vlodavsky

Zurit Levine

Gad S Cojocaru

Ronen Shemesh

Michal Ayalon-Soffer

Sergey Nemzer

Iris Hecht

Gil Arvatz

Tomer Zekharya

Marina Weissmann

Flonia Levy-Adam

Uri Barash

The present invention relates to heparanase-neutralizing monoclonal antibodies (m Abs), pharmaceutical composition comprising same, and use thereof for treating a disease or disorder associated with heparanase activity, including but not limited to cancer, inflammation, diabetes and related complications. The present invention further provides combined therapies comprising the heparanase-neutralizing m Ab and an anti-cancer treatment such as chemotherapy or radiation, for treating a proliferative disease in a subject.

Heparanase-neutralizing monoclonal antibodies

The present invention, in at least some aspects, is of splice variants of heparanase, as well as diagnostic kits and methods of use, and therapeutic agents and methods of use based thereon, and antibodies specifically binding thereof.

Heparanase splice variant

An amino acid sequence derived from the N' terminus region of the 50 Kd subunit of heparanase, preferably, the sequence including amino acid residues Lys-Asnof human heparanase and any functional fragments thereof. Compositions for the inhibition of heparanase glycosidase catalytic activity, having as an active ingredient an isolated and purified peptide as the amino acid sequence. An antibody directed to the sequence and compositions and uses thereof as heparanase inhibitor. The use of the amino acid sequence in a screening method for specific heparanase inhibitors. Compositions including the heparanase inhibitors and methods for the treatment of heparanase related disorders.

Substances directed against a specific sequence essential for heparanase catalytic activity and uses thereof as heparanase inhibitors

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Neta Ilan