Pfizer Hospital Products Group, Inc.

Pfizer Hospital Products, Inc.

Nestor A Arroyo

Casper F Stark

Jessica Dee Posey-Dowty

Paul A Higham

Raymond W Augustin

There is disclosed a bone cement composition comprising (a) a liquid component comprising a monomer of an acrylic ester and (b) a powdered component comprising a terpolymer of methyl methacrylate, butyl methacrylate, and styrene. A prepared terpolymer, based on the weight of the powdered component, has between 55 to 89.5% methyl methacrylate, 10 to 40% butyl methacrylate and 0.5 to 5% styrene.

Bone cement

A bone cement is disclosed wherein the liquid component contains a therapeutic or diagnostic substance in combination with an emulsifying agent for said substance.

Bone cement for sustained release of substances

A method and apparatus for use in reducing the volatilization of the monomer component of bone cement is used after a prosthesis is implanted and throughout the polymerization of bone cement. The apparatus includes a generally annular inflatable sealing member having a centrally located opening therein for fitting over the exposed end of the prosthesis. The sealing member has an outer diameter covering the exposed surface of the bone cement. The sealing member has a deformable surface disposed in a substantially co-planar relationship with the exposed surface of the bone cement. The sealing member is resiliently expandable by inflation and extends beyond the edges of the bone defining the cavity, to seal the bone cavity upon the deformation of the deformable surface thereon. A pump is provided for inflating the sealing member and causing the deformable surface to apply pressure to the exposed surface of the bone cement. A valving system and a pressure gage are used for controlling the pressure applied to the exposed surface of the bone cement within a range of from 8-14 psi.

Pressurization of bone cement surrounding an endoprosthesis

There is disclosed a bone cement composition comprising (a) a liquid component comprising a monomer of an acrylic ester and (b) a powdered component comprising, based on the weight of the powdered component,

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East Windsor, NJ, United States of America

Nestor A Arroyo