Centro De Immunologia Molecular

Centro De Inmunologia Molecular

Neris Michel Enamorado Escalona

Kalet León Monzón

Tania Carmenate Portilla

Saumel Pérez Rodriguez

Agustin Bienvenido Lage Dávila

Saumel Pérez Rodríguez

Agustin Bienvenido Lage Davila

Kalet LEÓN MONZÓN

Agustín Bienvenido Lage Davila

Kalet Leon Monzon

Saumel Perez Rodriguez

The present invention relates to polypeptides which share primary sequence with human IL-2, except for several amino acids that have been mutated. The mutations introduced substantially reduce the ability of these polypeptides to stimulate in vitro and in vivo regulatory T cells (T CD4+CD25+FoxP3+) and make them more effective in the therapy of murine transplantable tumors. Also includes therapeutic uses of these mutated variants, used alone or in combination with vaccines for the therapy of diseases such as cancer or infections where the activity of regulatory T cells (Tregs) is relevant. In another aspect the present invention relates to pharmaceutical compositions comprising as active principle the polypeptides disclosed. Finally, the present invention relates to the therapeutic use of the polypeptides and pharmaceutical compositions disclosed due to their modulating effect of the immune system on diseases like cancer and chronic infectious diseases.

IL-2 derivative polypeptides

Growing community of inventors

Havana, Cuba

Neris Michel Enamorado Escalona