Glaxosmithkline Intellectual Property Development Limited

Laboratoires Glaxo S.a.

Smithkline Beecham Corporation

Lilly Icos LLC

Nerina Dodic

Anne Marie Jeanne Bouillot

Michael Lawrence Sierra

Bernard Andre Dumaitre

Jason Scott Sawyer

Mark W Orme

Alain Claude-Marie Daugan

Francoise Jeanne Gellibert

Agnes Bombrun

Romain Luc Gosmini

Anne Bouillot

Pascal Maurice Pianetti

Bernard André Dumaître

The invention relates to activators of soluble guanylate cyclase and their use in pharmaceutical compositions, primarily topically administered ophthalmic compositions. The pharmaceutical compositions are useful for reducing intraocular pressure in animals of the mammalian species.

Soluble guanylate cyclase activators and their use

A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, wherein: 

Phenyloxyalkanonic acid derivatives as hPPAR activators

Compounds of the general structural formulaand use of the compounds and salts and solvates thereof, as therapeutic agents.

Carboline derivatives

Certain isoquinoline derivatives having anti-tumor properties

These are provided compounds of formula I ##STR1## wherein A represents an oxygen or a sulphur atom, a bond or a group (CH.sub.2).sub.1 NR.sup.9 (where 1 represents zero or 1 and R.sup.9 represents a hydrogen atom or a methyl group); B represents a C.sub.1-4 alkylene chain optionally substituted by a hydroxyl group, except that the hydroxyl group and moiety A can not be attached to the same carbon atom when A represents an oxygen or sulphur atom or a group (CH.sub.2).sub.1 NR.sup.9, or when A represents a bond B may also represent a C.sub.2-4 alkenylene chain; R.sup.3 represents a hydrogen atom or a C.sub.1-4 alkyl group; m represents 1 or 2; R.sup.7 represents a hydrogen atom or R.sup.3 and R.sup.7 together form a group --(CH.sub.2).sub.n -- where n represents 1 or 2. These compounds can sensitize multidrug-resistant cancer cells to chemotherapeutic agents and may be formulated for use in therapy, particularly to improve or increase the efficacy of an antitumor drug.

Acridine derivatives

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Les Ulis, France

Nerina Dodic