University of Washington

Vanderbilt University

University of Montana

Nephi Stella

Darryl J Bornhop

Toni Beth Kline

Philippe Diaz

Mingfeng Bai

Eric Stern

This disclosure relates to compounds that target microtubules, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases. More particularly, this disclosure relates to modified carbazole compounds and pharmaceutical compositions thereof, methods of targeting microtubules with these compounds, and methods of treating diseases affected by microtubule disruption.

Modified carbazoles as therapeutic agents

The disclosure provides methods of treating glioblastoma, methods of screening for compounds that treat glioblastoma, and pharmaceutical compositions useful the treatment of glioblastoma. 

Composition and methods for treating glioblastoma

Compounds of the following formula: wherein X is H or substituted with with at least one X being substituted; and halo is fluorine, chlorine, bromine, iodine; and stereoisomers and conjugable analogs thereof.

Cannabinoid receptor targeted agent

Growing community of inventors

Seattle, WA, United States of America

Nephi Stella