Biora Therapeutics, Inc.

Progenity, Inc.

Lombard Medical Limited

Shimizu, Jeffrey A.

Wahl, Christopher Loren

Bunce, Christopher Ian

Mudge, Edward

Jones, Mitchell Lawrence

Stevens, Nia Eleri

Salt, Nicholas Mark

Abercombie, Stuart Robert

Muller, Nathan John

Niknia, Iman

Nguyen, Tuyen

Drlik, Mark Sasha

Nelson Quintana

Mitchell Lawrence Jones

Christopher Loren Wahl

Mark Sasha Drlik

Nathan John Muller

Tuyen Nguyen

Jeffrey A Shimizu

Iman Niknia

Edward Mudge

Christopher Ian Bunce

Stuart Robert Abercrombie

Nia Eleri Stevens

Nicholas Mark Salt

Kevin Howe

Pejman Rahimian

Andrew H Cragg

John B Logan

George Tsai

Ryan Elliott Jones

Mahmood Dehdashtian

Kevin David Howe

Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Ingestible device for delivery of therapeutic agent to the gastrointestinal tract

A method of treating a disease or condition in a subject in need thereof is disclosed. The method comprising: trans-epithelially administering a dispensable substance to the gastrointestinal (GI) tract of the subject by orally administering an ingestible device comprising the dispensable substance to the subject. The ingestible device is configured for trans-epithelial delivery of the dispensable substance to the GI tract of the subject and the dispensable substance comprises a pharmaceutical formulation comprising a therapeutically effective amount of a glucagon receptor agonist or a glucagon-like peptide-1 (GLP-1) receptor agonist. The ingestible device releases the dispensable substance as at least one jet to a desired location of the GI tract of the subject.

An ingestible device, includes a storage reservoir configured to store a dispensable substance and a pressurized chamber configured so that, when a restraining force is removed from the pressurized chamber, the dispensable substance exits the ingestible device via openings in the ingestible device.

Stent delivery systems and associated methods for delivering stents are disclosed herein. In several embodiments, a handle assembly for delivering a stent from a tubular enclosure can include a first lead screw having a first lead thread of a first pitch and first handedness, a second lead screw having a second lead thread of a second pitch and second handedness different from the first handedness, and a housing defining threads of the first and second pitches. The first lead screw can be in mechanical communication with the tubular enclosure, and the second lead screw can be in mechanical communication with the stent. Upon rotation of a portion of the housing, the housing threads can engage the lead screws so as to induce simultaneous translations of the lead screws in opposite directions. The simultaneous translations are configured to deploy the stent from the tubular enclosure.

Stent delivery systems and associated methods

Growing community of inventors

Temecula, CA, United States of America

Nelson Quintana