Merrell Pharmaceuticals, Inc.

Merrell Dow Pharmaceuticals

Nellikunja J Prakash

Terry L Bowlin

James R Mccarthy

James R McCarthy

Michael L Edwards

David M Stemerick

Esa T Jarvi

Sai P Sunkara

This invention relates to a method of potentiating cell-mediated immunity which comprises administering to a patient a cell-mediated immunity potentiating amount of a compound of the formula:

Method of potentiating cell-mediated immunity utilizing polyamine

The present invention relates to a method of treating a patient suffering from a neoplastic disease state comprising administering to said patient an effective antineoplastic amount of N,N'-bis[3-(ethylamino)propyl]-1,7-heptanediamine in conjunctive therapy with an effective antineoplastic amount of a cytotoxic agent selected from the group consisting of an antineoplastic vinca alkaloid, an antineoplastic antibiotic, an antineoplastic antimetabolite and an antineoplastic platinum coordination complex, wherein a synergistic antineoplastic effect results.

Method of treating cancer by conjunctive therapy with N,N.sup.1

The present invention relates to a method for the treatment of patients suffering from certain neoplastic disease states which comprises administering a therapeutically effective amount of a compound of the formula: ##STR1## wherein m is an integer 6 to 9, Z is a saturated (C.sub.2 -C.sub.6) alkylene moiety, each R group independently is hydrogen, methyl, ethyl, or n-propyl except that both R groups cannot be hydrogen when Z is a straight chain; or a pharmaceutically acceptable acid addition salt thereof. Said treatment can optionally comprise conjunctive therapy with a polyamine oxidase inhibitor. The invention also relates to certain novel polyamine derivatives.

Polyamine derivatives as antineoplastic agents

Method of treating cancer by conjunctive therapy with

This invention relates to certain aristeromycin/adenosine derivatives which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.

Aristeromycin analogues of 4',5'-didehydro-5'-fluoro-adenosine and

The present invention relates to certain novel polyamine compounds of the formula: ##STR1## wherein Z is a saturated (C.sub.2 -C.sub.6) alkylene moiety, each R group independently is hydrogen, methyl, ethyl, or n-propyl with the provisos that both R groups cannot be hydrogen and that R is hydrogen or methyl when Z is a branched chain alkylene; or a pharmaceutically acceptable acid addition salt thereof.

5'-deoxy-4',5'-unsaturated-5'-substituted adenosines

This invention relates to certain acetylenic, cyano and allenic aristeromycin/adenosine derivatives which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.

Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group

This invention relates to the improvement of the polyamine depletion effects of ornithine decarboxylase inhibitors and/or S-adenosylmethionine decarboxylase inhibitors, the improvement being effected by the use of interferon in conjunctive therapy with said inhibitors.

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Cincinnati, OH, United States of America

Nellikunja J Prakash