University of Massachusetts

Nele Van Dessel

Neil S Forbes

Shane S Taylor

John Klier

Vishnu Raman

Provided herein are compositions comprising nanoparticles, wherein the nanoparticles comprise at least one payload, wherein the nanoparticles further comprise at least one surface bound functional group and method of their use.

Localization of payload delivery systems to tumor sites via beacon cell targeting

One embodiment provides an attenuatedstrain comprising a lysis gene or cassette operably linked to an intracellularly inducedpromoter. In one embodiment, the promoter is a promoter for one of the genes inpathogenicity island 2 type III secretion system (SPI2-T3SS) selected from the group SpiC/SsaB, SseF, SseG, SseI, SseJ, SseK1, SseK2, SifA, SifB, PipB, PipB2, SopD2, GogB, SseL, SteC, SspH1, SspH2, or SirP. In one embodiment, agene is under the regulation of an inducible promoter, wherein the gene is selected from ftsW, ftsA, ftsZ, murE, mukF, imp, secF, eno, hemH, tmk, dxs, uppS, cdsA, accA, pssA, msbA, tsf, trmD, cca, infB, rpoA, rpoB, rpoC, holA, dnaC, or eng. In one embodiment, thestrain further comprises a plasmid that expresses DNA, shRNA, non-coding RNA and/or a peptide.

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Amherst, MA, United States of America

Nele Van Dessel