Nv Remynd

Nele Van Damme

Gerard Griffioen

Stefaan Wera

Hein Roger Duhamel

Ellen Gommé

Tom Van Dooren

Kristel Marie Edith Coupet

Ingrid Van Der Auwera

Marleen Lox

Tine Decruy

Ellen Gomme

Kristel Marie Coupet

This invention provides specifically substituted 1,2,4-thiadiazole derivatives for use in the treatment of an &#x3b1;-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease. This invention also provides various methods for producing such substituted 1,2,4-thiadiazole derivatives.

Thiadiazole derivatives for the treatment of neurodegenerative diseases

The invention provides novel 1,2,4-thiadiazole derivatives useful for preventing or treating an &#x3b1;-synucleopathy such as Parkinson's disease, as well as pharmaceutical compositions including them as biologically active ingredients, and methods for manufacturing them. 

Thiadiazole derivatives for the treatment of neuro-degenerative diseases

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Kessel-lo, Belgium

Nele Van Damme