Abbott Laboratories Corporation

Spectrx, Inc.

Neil W Loomis

Mark R Pope

Michael G Lowery

Thomas G Schapira

John P Grace

Timothy P Henning

Peter M Bojan

Eric B Shain

Andrew J Muetterties

Gary M Oosta

David Dean Cunningham

John J Kotlarik

Tung-Ming Huang

Robert G Hiltibran

Sie Ting Wong

Brian Joseph Tarkowski

Douglas D Hansmann

Pete M Bojan

Daniel P Schmidt

Kristin M Noonan

Jonathan Eppstein

Peter N Bojan

The present invention involves apparatus and methods for use in collecting bodily fluids, such as interstitial fluids, from the epidermal layer of an animal. A preferred apparatus includes a pressure head and, optionally, a holder therefor for supplying a positive pressure to the head. The methods include the application of a positive pressure to the area surrounding an epidermal site from which stratum corneum has been breached, such as by laser ablation, to cause bodily fluids, such as interstitial fluids, to exude from the site and collecting the fluids exuding therefrom.

Apparatus and method for the collection of interstitial fluids

Fluid collection and monitoring device

Removal of stratum corneum by means of light

A method for increasing the permeability of the stratum corneum by means of a source of light, preferably a laser, more preferably a pulsed laser. By increasing the permeability of the stratum corneum, access to the interstitial fluid is achieved, thereby enabling measurement of analytes in the interstitial fluid. In one aspect, the method comprises the steps of:

The present invention relates to analytical devices for determining the presence or amount of an analyte in a test sample. The analytical devices comprise an inlet port, a vent, a channel, and an array of structures. The structures have immobilized reagent covalently or non-covalently attached to the surface of the structures. The immobilized reagent captures analyte in the test sample where it is detected by a detection system. The present invention also provides methods and reagents for performing assays utilizing the analytical devices of the present invention. The present invention also provides methods of manufacturing the analytical devices of the present invention.

Devices and methods utilizing arrays of structures for analyte capture

Growing community of inventors

Racine, WI, United States of America

Neil W Loomis