The General Hospital Corporation

Whitehead Institute for Biomedical Research

The General Hospital Corporation D/b/a Massachusetts General Hospital

Neil Vasdev

Hidde L Ploegh

Huan Steven Liang

Nickeisha A Stephenson

Timothy M Shoup

Mohammad Rashidian

Benjamin H Rotstein

Huan Liang

The present application provides compounds useful in methods of treating neurological disorders such as Alzheimer's disease, and cancer such as prostate cancer. Also provided herein are radiolabeled compounds useful for imaging techniques, and techniques for diagnosis and monitoring of treatment of neurological disorders and cancer. An exemplary radiolabeled compound provided herein is useful as a radiotracer for positron emission tomography or single-photon emission computed tomography. Methods for preparing radiolabeled compounds and methods for preparing unlabeled compounds are also provided.

8-hydroxyquinoline derivatives as diagnostic and therapeutic agents

Provided herein are radiolabelled compounds useful for imaging GSK-3 kinase. An exemplary radiolabelled compound provided herein is useful as a radiotracer for imaging GSK-3 kinase using PET imaging. Methods for preparing the radiolabelled compounds and diagnostic methods using the radiolabelled compounds are also provided.

Imaging of glycogen synthase kinase 3

A process for fluorination of aromatic compounds employing iodonium ylides and applicable to radiofluorination usingF is described. Processes, intermediates, reagents and radiolabelled compounds are described.

Method of fluorination using iodonium ylides

Iodine(II)-mediated radiofluorination

This disclosure relates to a one-step method for preparing the tau radiopharmaceutical, [18F]T807, using an unprotected or protected precursor (e.g., tert-butyl 7-(6-nitropyridin-3-yl)-5H-pyrido[4,3-b]indole-5-carboxylate).

Radiosynthesis of tau radiopharmaceuticals

Iodine(III)-mediated radiofluorination

Growing community of inventors

Cambridge, MA, United States of America

Neil Vasdev