Axys Pharmaceuticals, Inc.

Neil Scott Cutshall

Martin Sheringham Linsell

Thomas E Jenkins

Timothy J Church

Kenneth D Rice

Joane Litvak

Jeffrey R Spencer

Anthony R Gangloff

Vivian R Wang

Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis, as well as other types of immunomediated inflammatory disorders, such as rheumatoid arthritis, conjunctivitis and inflammatory bowel disease, various dermatological conditions, as well as certain viral conditions. The compounds comprise potent and selective inhibitors of the mast cell protease tryptase. The compositions for treating these conditions include oral, inhalant, topical and parenteral preparations as well as devices comprising such preparations.

Compositions comprising a substituted benzimidazole useful for treating immunomediated inflammatory disorders

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San Mateo, CA, United States of America

Neil Scott Cutshall