Aventis Pharmaceuticals Inc.

Neil Moorcroft

Philip M Weintraub

Shujaath Mehdi

Paul Robert Eastwood

Kwon Yon Musick

John Ziqi Jiang

Jack Roger Koehl

Stefan Peukert

Sungtaek Lim

Uwe Schwahn

David Stefany

Paul R Eastwood

David W Stefany

The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: wherein R, R, R, Rand Rare as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5'-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.

Substituted pyridones as inhibitors of poly(ADP-ribose) polymerase (PARP)

The present invention relates to a series of substituted aza-indole derivatives of the formula I: wherein R, R, R, R, R, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5'-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.

Substituted AZA-indoles as inhibitors of poly(ADP-ribose) polymerase (PARP)

The present invention relates to a series of substituted indole derivatives of the formula I: 

Substituted indoles as inhibitors of poly (ADP-ribose) polymerase (PARP)

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Bloomsbury, NJ, United States of America

Neil Moorcroft