Smithkline Beecham Corporation

Reviral Limited

Astrazeneca Ab

Arrow Therapeutics Limited

Neil Mathews

Alan Naylor

Paul John Beswick

Ian B Campbell

Richard Angell

Stuart George Cockerill

James Lumley

Stuart Cockerill

Christopher Pilkington

Malcolm Clive Carter

Simon Ward

Andrew Jonathan Whitehead

James Iain Salter

Richard Anthony Ward

Lyn Jennens

Graham Lunn

Jose Miguel Gascon Simorte

Michael Paradowski

Christopher James Wheelhouse

Alexander James Floyd Thomas

David John Bushnell

Keith Charles Spencer

Christopher John Pilkington

Nathalie Tiberghien

Surinder Chana

Ian John Fraser

Richard Martyn Angell

Benzimidazoles of formula (I): wherein: one of X and Y is an N atom or a substituted C atom, and the other is CH; L is a single bond, Calkylene, Calkenylene or Calkynylene; Ris Calkyl, Calkenyl, Calkynyl, 3- to 10-membered cycloalkyl, 5- to 10-membered heterocyclyl or 5- to 12-membered heteroaryl, each of which is unsubstituted or substituted; Z is halo, Chaloalkyl, nitro, &#x2014;CN, &#x2014;N(R)2, &#x2014;OR, &#x2014;SR, &#x2014;S(=0)R, or &#x2014;S(=0)R; each Ris independently hydrogen, Calkyl, Calkenyl or C2-6 alkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; and m is 0 or 1; and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection. 

Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (RSV)

Benzimidazoles of formula (I): wherein: A is 5- to 12-membered aryl or 5- to 12-membered heteroaryl, each of which is unsubstituted or substituted; Y is a single bond, &#x2014;(CH)&#x2014;, &#x2014;X&#x2014;, &#x2014;CH&#x2014;X&#x2014;, or &#x2014;X&#x2014;CH&#x2014;; X is &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;N(R)&#x2014;, &#x3e;C&#x2550;O, &#x3e;S(&#x2550;O), &#x3e;S(&#x2550;O), &#x2014;O&#x2014;C(&#x2550;O)&#x2014;, &#x2014;C(&#x2550;O)&#x2014;O&#x2014;, N(R)&#x2014;C(&#x2550;O)&#x2014;, or &#x2014;C(&#x2550;O)&#x2014;N(R)&#x2014;; each L is independently a single bond, Calkylene, Calkenylene or Calkynylene; Ris Calkyl, Calkenyl or Calkynyl, each of which is unsubstituted or substituted; each Z is independently &#x2014;N(R), &#x2014;OR, &#x2014;SR, &#x2014;S(&#x2550;O)R, &#x2014;S(&#x2550;O)R; each Ris independently hydrogen, Calkyl, Calkenyl or Calkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; m is 0, 1, 2, or 3; n is 1, 2, or 3; and p is 1, 2, or 3; and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection. 

Pharmaceutical compounds

Use of a compound which is a biphenyl derivative of formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of Hepatitis C wherein the variables are described herein.

Biphenyl derivatives and their use in treating hepatitis C

2,3-diaryl-pyrazolo&lsqb;1,5-B&rsqb;pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (COX-2) inhibitors

Process for the preparation of pyrazolopyridine derivatives

The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof in which: R is halogen, C alkyl, C alkoxy, C alkoxy substituted by one or more fluorine atoms, or O(CH ) NR R ; R and R are independently selected from H, C alkyl, C alkyl, substituted by one or more fluorine atoms, C alkoxy, C hydroxyalkyl, SC alkyl, C(O)H, C(O)C alkyl, C alkylsulphonyl, C alkoxy substituted by one or more fluorine atoms, O(CH ) CO C alkyl, O(CH ) SC alkyl, (CH ) NR R , (CH ) SC alkyl or C(O)NR R ; with the proviso that when R is at the 4-position and is halogen, at least one of R and R is C alkylsulphonyl, C alkoxy substituted by one or more fluorine atoms, O(CH ) CO C alkyl, O(CH ) SC alkyl, (CH ) NR R or (CH ) SC alkyl, C(O)NR R ; R is C alkyl or NH ; R and R are independently selected from H, or C alkyl or, together with the nitrogen atom to which they are attached, form a 4-8 membered saturated ring; and n is 1-4. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.

2,3-Diaryl-pyrazolo&lsqb;1,5-b&rsqb;pyridazines derivatives, their preparation and their use as cyclooxygenase 2(COX-2) inhibitors

Growing community of inventors

London, United Kingdom

Neil Mathews