Zimmer Gmbh

Isto Technologies, Inc.

Neil Kizer

Cheryl Renee Blanchard

Robert C Spiro

Jian Yao

Huston Davis Adkisson

Curt L Milliman

Michael O Maloney

Gary B Gage

Nicole M Bergmann

Michael Maloney

Iv H Davis Adkisson

Gary Gage

The present disclosure relates to cartilage repair compositions and methods for modifying the proteoglycan content of the compositions. Specifically, the methods relate to serum free, collagen free neocartilage made from chondrocytes that can be used for implants. Proteoglycans, such as aggrecan and sulfated glycosaminoglycan are used and the content modified using temperature changes.

Neocartilage compositions and methods for modifying proteoglycan content

The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.

Treatment methods using a particulate cadaveric allogenic juvenile cartilage particles

Particulate cadaveric allogenic cartilage system

Particulate cartilage system

Juvenile cartilage composition

Cadaveric allogenic human juvenile cartilage implant

Method of treating an osteochondral defect

The present invention provides a method for expanding a population of chondrocytes that maintains chondrocyte phenotype during the expansion by culturing the population in a defined serum-free expansion medium containing one or more cytokines and under low attachment conditions. The method further solves diffusion problems during the subsequent stage of extracellular matrix production by use of a perforated polycarbonate substrate that results in a randomly organized cultured neocartilage tissue. Chondrocytes expanded and cultured in this manner can be used in various medical applications to repair cartilaginous tissues that have been injured by trauma or disease.

Method for chondrocyte expansion with phenotype retention

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Crestwood, MO, United States of America

Neil Kizer