Johnson Matthey Public Limited Company

Resolution Chemicals Limited

Neil John Goodwin

Alan Kenneth Greenwood

Nicolas Archer

George Scott Wilson

Maureen Young

Melville Mitchell

Derek Mchattie

Neil Kenneth Thomson

Christopher Murray

Maureen Joan Young

Nicolas James Archer

A process for preparing a compound of formula (A), (B) or (C): wherein P is H, CHor a hydroxyl protecting group; X is O, a protected ketone, OH, a protected hydroxyl group or H; Y is OH, a protected hydroxyl group or H; W is C(CH)OH, C(CH)(C(CH))OH or COCH; Z is C-Calkyl or C-Carylalkyl; andis a single bond or a double bond, is disclosed. The process is a reductive alkylation in the presence of hydrogen and a reductive alkylation catalyst.

Preparation of opiate analgesics by reductive alkylation

A process for preparing a compound of formula (A), (B) or (C): wherein P is H, CHor a hydroxyl protecting group; X is O, a protected ketone, OH, a protected hydroxyl group or H; Y is OH, a protected hydroxyl group or H; W is C(CH)OH, (CH)(C(CH))OH or COCH; Z is C-Calkyl or C-Carylalkyl; andis a single bond or a double bond, is disclosed. The process includes reductive alkylation in the presence of hydrogen and a reductive alkylation catalyst.

&#x394;9 THC acid is obtained from plant material and extracted into an aqueous solvent under conditions of pH control. The acid is converted to a salt and the salt extracted into a polar solvent, yielding acid of high purity. The &#x394;9 THC acid is then converted to &#x394;9 THC which is further purified and combined with a carrier for pharmaceutical use.

Production of &#x394; 9 tetrahydrocannabinol

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Edinburgh, United Kingdom

Neil John Goodwin