Salford Ultrafine Chemicals & Research Ltd.

Neil Edward Carter

Feodor Scheinmann

Richard Talbot Brown

Stephen Patrick Mayalarp

Keith William Lumbard

Nicholas John Turner

##STR1## Morphine-6-glucuronide or substituted morphine-6-glucuronide of formulae (I) is made by conjugation of a glucuronate ester and/or substituted glucuronate ester with morphine or substituted morphine in the presence of a Lewis acid catalyst and in the absence of silver catalysts and barium hydroxide and other heavy metal derivatives.

Process for making morphine-6-glucuronide or substituted

A method of making morphine-6-glucuronide comprising the selective enzymatic cleavage of the 3-glucuronide moiety in morphine-3, 6-glucuronide or substituted morphine-6-glucuronide using at least one .beta.-glucuronide.

Growing community of inventors

Manchester, United Kingdom

Neil Edward Carter