Glaxo Group Limited

Smithkline Beecham Corporation

Neil Derek Miller

Andrew McMurtrie Mason

Gerard Martin Paul Giblin

Alan D Borthwick

John Liddle

Paul Graham Wyatt

Deirdre Mary Bernadette Hickey

Anna Katrin Szardenings

Steven Leslie Sollis

David George Hubert Livermore

Fabrizio Nerozzi

Richard Jonathan Hatley

Ann Louise Walker

Susan Roomans

Miles Stuart Congreve

David Nigel Hurst

Mark Patrick Healy

Adrian Hall

Ian Reginald Kilford

Rino Antonio Bit

Tiziana Scoccitti

Haydn Terence Jones

Stephen Edward Shanahan

A method of treating or preventing diseases or conditions mediated through the action of oxytocin which comprises administering to a human in need thereof of an effective amount of a compound of the formula (I) or a pharmaceutically acceptable salt thereof.

Substituted diketopiperazines as oxytocin antagonists

A method of treating or preventing diseases or conditions mediated through the action of oxytocin which comprises administering to a human in need thereof of an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.

Naphthalene derivatives

A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein Rto R, X, and Y are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.

Benzoisoindole derivatives and their use as EP4 receptor ligands

A method of treating or preventing diseases or conditions mediated through the action of oxytocin which comprises administering to a mammal in need thereof of an effective amount of a compound of the formula (I) and/or a physiologically acceptable derivative thereof, wherein the substituents have the meaning given in the description. Disclosed are also novel compounds of formula (I) and processes for their preparation.

Compounds of formula (I) or derivatives thereof: wherein A, B, Z, R, R, R, R, R, and Rare as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.

Phenyl compounds

Compounds of formula (I)and pharmaceutically acceptable derivatives thereof bind with high affinity to the EP4 receptor and are of use in the treatment or prevention of conditions such as a pain, inflammatory, immunological, bone, neurodegenerative or renal disorder.

Naphathalene derivatives which bind to the EP4 receptor

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Harlow, United Kingdom

Neil Derek Miller