Glaxo Group Limited

Smithkline Beecham Corporation

Shionogi Company Limited

Glaxosmithkline Intellectual Property Development Limited

Other

Korea Research Institute of Chemical Technology

Neil David Pearson

David Thomas Davies

Roger Edward Markwell

Graham Elgin Jones

Israil Pendrak

William Henry Miller

Alan Joseph Hennessy

Timothy James Miles

Robert A Daines

Jeffrey Michael Axten

Andrew Lightfoot

Ilaria Giordano

Gerald Brooks

Timothy Francis Gallagher

Mark Andrew Seefeld

Andrew Kenneth Takle

Qi Jin

Stephen Frederick Moss

Guy Marguerite Marie Gerard Nadler

Xiangmin Liao

Jose Maria Fiandor Roman

Haifeng Cui

Catherine Genevieve Yvette Dartois

Alan Hennessy

Jun Sato

Toshiaki Aoki

Michael N Gwynn

Bong Jin Kim

Steven Dabbs

Kenji Yamawaki

Edwina Imogen Wilding

Tae Ho Park

David Barros-Aguirre

Julia Castro Pichel

Masayuki Sano

Wan Joo Kim

Carlos Alemparte-Gallardo

Moon Hwan Kim

Katsuki Yokoo

Hiroki Kusano

Monica Cacho-Izquierdo

Modesto J Remuiñan Blanco

Jason Anthony Rossi

James B Hoffman

Lihua(lily) Zhang

Nathalie Cailleau

David Evan Davies

Symon G Erskine

Christopher Barfoot

Reema K Thalji

Modesto Jesus Remuinan-Blanco

Lluis Ballell

David Barros

Senthil Kumar Kusalakumari Sukumar

Joel Michael Esken

The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and treatment methods or uses as antibacterials for bacterial infections.

Compounds for use in antibacterial applications

The compounds of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.

2 substituted cephem compounds

The present invention relates to cephalosporin antibacterial compounds of Formula (I): or corresponding pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods for bacterial infections, especially those caused by gram-negative bacteria.

Antibacterial compounds

Tricyclic nitrogen containing compounds and their use as antibacterials. Zand Zare independently selected from CH and N. 

Tricyclic nitrogen containing compounds as antibacterial agents

Compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides thereof: (relative chemistry shown) pharmaceutical compositions comprising them, their use in therapy especially against tuberculosis, and methods of preparing them are described.

Compounds

Bicyclic nitrogen containing compounds and their use as antibacterials.

Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones

Tricyclic nitrogen containing compounds of formula (I) and their use as antibacterials.

Heterocyclic compounds, their preparation and their use as antibacterials

Tryclic nitrogen containing compounds and their use as antibacterials

Tricyclic nitrogen containing compounds and their use as antibacterials.

Pyrrolo-quinoxalinone derivatives as antibacterials

Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.

Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man 

Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity

Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. The piperidine derivatives include compounds of formula (I): wherein R, AB, n, R, Rand Rare defined herein. For example, Ris an optionally substituted bicyclic carbocyclic or heterocyclic ring system, and Ris a group U-Rin which Ris an optionally substituted bicyclic heterocyclic ring system as defined herein (e.g. optionally substituted pyrido [3,2, -b][1,4] thiazin-yl).

Quinoline and naphthridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans.

Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents

Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.

Aminopiperidine derivatives

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Harlow, United Kingdom

Neil David Pearson