Allied Corporation

Instrumentation Laboratory

Neil D Silverman

Alan D Cormier

Milo E Webster

John D Czaban

William R Oliver

Bruno DeGironimo

Lynn W Noble

Eugene C Rideout

An interactive injection system for use with a catheter of the type adapted for insertion into a patient's vascular system for thermodilution measurements and the like includes a chamber for storing liquid injectate, means for connecting the chamber to the catheter lumen, and a drive for operating on the chamber to flow liquid injectate from the chamber into the lumen for discharge as a bolus from the lumen into the vascular system of a patient. In preferred embodiments, a temperature sensing probe is connected between the injection chamber and the catheter for monitoring the temperature of injectate as it is introduced into the catheter. Cooperating controller apparatus includes means for operating the drive, operator controlled inputs for selecting injectate rate and volume parameters, another operator controlled input for enabling the injector drive, an input from a sensor adapted to be located in the patient's vascular system downstream from the proximal port and operative during an injection cycle in response to a sensed deviation of output (e.g., out of specification for terminating the injection sequence, and a processor for utilizing (e.g., integrating) the sensor output to generate a cardiac output value or similar data.

Injection system

A system for analyzing a biological fluid specimen or the like includes an analysis chamber and an electrochemical electrode measuring system connected in sensing relation to the analysis chamber. A flow network connects a sample inlet port and an auxiliary fluid reservoir to the analysis chamber. The flow network includes a sample line connected between the sample inlet port and the analysis chamber and an auxiliary manifold connected to the auxiliary fluid reservoir. A positive displacement pump is connected in the sample line between the analysis chamber and a waste outlet port. A valved T-connection is provided between the sample line and the manifold; an inlet isolation valve is in the sample flow path between the sample inlet and the valved T-connection; an analysis chamber isolation valve is in the sample flow path between the valved T-connection and the analysis chamber; and both the sample line and the manifold have a vent valve, the sample line vent valve being connected between the inlet and chamber isolation valves and the manifold vent valve being connected upstream of the auxiliary fluid reservoir. Coordinated operation of the several valves permits the pump to selectively flow fluid from the auxiliary reservoir or a sample through the analysis chamber, together with imposition of nonlaminar flow conditions by concurrent operation of the vent valves to provide effective cleaning of flow surfaces and analysis chambers.

Analysis system

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Framingham, MA, United States of America

Neil D Silverman