Merck Sharp + Dohme Corp.

Neil Campbell

John S Wai

Peter D Williams

Shankar Venkatraman

Wayne J Thompson

Dai-Shi Su

Peter Emmanuel Maligres

Mark W Embrey

Zhiguo Jake Song

Thorsten E Fisher

Tao Pei

Jingjun Yin

David C Dubost

Richard C A Isaacs

Michael Shevlin

Neil A Strotman

Dietrich P Steinhuebel

Matthew L Maddess

Richard G Ball

Eric J Choi

Sarah L Trice

Matthew Maddess

Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: wherein X, X, Y, R, R, Rand Rare defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Processes for making compounds of Formula I and intermediates thereof are also described.

HIV integrase inhibitors

Growing community of inventors

Cherry Hill, NJ, United States of America

Neil Campbell