Incyte Corporation

Bristol-Myers Squibb Compnay

Neil Burford

Mariah R Baughn

Henry Yue

Dyung Aina M Lu

April J A Hafalia

Monique G Yao

Ameena R Gandhi

Yan Lu

Li Ding

Olga Bandman

Preeti G Lal

Y Tom Tang

Craig H Ison

Junming Yang

Bridget A Warren

Anita Swarnakar

Yuming Xu

Brendan M Duggan

Vicki S Elliott

Narinder K Chawla

Bao M Tran

Kimberly J Gietzen

Madhusudan M Sanjanwala

Michael Thorton

Cynthia D Honchell

Sally Lee

Janice K Au-Young

Chandra S Arvizu

Danniel B Nguyen

Rajagopal Gururajan

Catherine M Tribouley

Narinder K Walia

Jayalaxmi Ramkumar

Kavitha Thangavelu

Stephanie Kareht

Kavitha Thangaveln

Roopa M Reddy

Michael B Thornton

Farrah A Khan

Stephanie K Sapperstein

Liam Kearney

Vicki S Kaulback

Ernestine A Lee

Yalda Azimzai

Angelo M Delegeane

Ian J Forsythe

Gregory Marcus

Jennifer L Policky

Debopriya Das

John D Burrill

Andrew Alt

Kurt A Zingler

Vicki S Elliott Kaulback

Preeti G Lai

Jennifer A Griffin

Stephen Todd

Deborah A Kallick

Mark L Borowsky

Roberto Hernandez

The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.

Secreted proteins

Disclosed are positive allosteric modulators (PAMs) and silent allosteric modulators (SAMs) for mu (&#x3bc;)-opioid receptors that may be useful for the treatment of pain, either alone or in combination with orthosteric opioid receptor agonists. Methods for treating pain and modulating mu (&#x3bc;)-opioid receptors are also disclosed.

Positive allosteric modulators and silent allosteric modulators of the Mu opioid receptor

Antibody to secreted polypeptide

The invention provides human G-protein coupled receptors (GCREC) and polynucleotides which identify and encode GCREC. The invention also provides expression vectors, host, cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of GCREC.

Isolated polynucleotide encoding a G-protein coupled receptor

The invention provides human human kinases (PKIN) and polynucleotides which identify and encode PKIN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PKIN.

Human cAMP-dependent protein kinase beta-catalytic subunit

The invention provides human kinases and phosphatases (KAP) and polnucleotides which identify and encode KAP. The invention also provides expresson vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KAP.

Human protein phosphatase 2C

The invention provides a human cysteine proteases and polynucleotides which encode those proteases. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists, as well as methods for diagnosing, treating, or preventing disorders associated with aberrant expression of cysteine proteases.

Proteases

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Durham, CT, United States of America

Neil Burford