Vaxiion Therapeutics, LLC

Rempex Pharmaceuticals, Inc.

Neil Berkley

Mark William Surber

Roger A Sabbadini

Robert Klepper

David C Griffith

Tomasz W Glinka

Olga Lomovskaya

Keith A Bostian

Matthew J Giacalone

Minicells are used to deliver biologically active compounds including radioisotopes, polypeptides, nucleic acids, small molecules, drug molecules, and chemotherapeutic agents. In some cases, the minicell displays ligands or binding moieties that target the minicell to a desired host cell.

Minicell based delivery of biologically active compounds

The disclosed invention relates to immunogenic minicells cells (anucleated) and their use to induce an immune response from a subject.

Immunogenic minicells and methods of use

Minicells displaying antibodies or derivatives thereof and comprising biologically active compounds

Efflux pump inhibitors are co-administered with antimicrobial agents for the treatment of ophthalmic or otic infections. The agents may be co-administered directly to the site of infection (e.g., the eye or ear).

Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections

Disclosed herein is a rhamnose-inducible expression vector.

Rhamnose-inducible expression constructs and methods

Th invention provides compositions and methods for the production of achromosomal and anucleate cells useful for applications such as diagnositic and therapeutic uses, as well as research tools and agents for drug discovery.

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San Diego, CA, United States of America

Neil Berkley