Hoffmann-la Roche Inc.

Genentech, Inc.

Shl Medical Ag

F. Hoffmann-la Roche Ag

Neil Bentley Cammish

Marcel Sigrist

Eszter Voros

Thomas Peter Stuedeli

Holger Roehl

Joseph Alexander Martin

Nariye Salibryam Cavusoglu Ataman

Maria Enterrios Quintana

Monica De Bardi

Guido Drees

Shreya Munjal

Stephan Olson

Declan Reilly

Markus Hemminger

Thomas Thueer

Flora Felsovalyi

Cyrille Blintz

Ian James Matthews

Richard Dumont

Matthieu Noël Claude Giletti

Martin Müri

Thomas Thüer

Jürg Liniger

Martin Muri

Jurg Liniger

Thomas Thuer

A closure system is disclosed for closing a container opening. The closure system includes a stopper member, a cage member for mounting to the container, and a spring member. The stopper member has a plug portion that tightly fits into the container opening and a cover portion that abuts a boundary surface adjacent to the container opening container. The stopper member plug portion is fitted into the container opening, the stopper member cover portion abuts the boundary surface of the container, and the cage member is mounted to the container to hold the stopper member, when the closure system is in an assembled state. The cage and spring members are arranged to position the spring member between the stopper member cover portion and the cage member such that the spring member pushes the cage member away from the cover portion when the closure system is in the assembled state.

Closure system and kit

A closure system for closing a container opening is disclosed that includes a stopper member, a cage member for mounting to a container, a cover member reversibly mountable to the cage member, and an integrity visualization member. The stopper member has a plug portion to fit into the container opening and a cover portion to abut a boundary surface of the container opening. The plug portion of the stopper member is fitted into the opening of the container and the cage member is mounted to the container. The cage member applies a force to the cover portion to push the cover portion onto the boundary surface of the container opening. The cover member covers an aperture of the cage member when mounted to the cage member. The integrity visualization member indicates an integrity of the closure system and is positioned between the cover portion and the cage member.

A closure system for closing a container opening is disclosed that includes a stopper member, a cage member and a lock activation formation. The stopper member includes a plug portion to fit into the container opening and a cover portion to abut a boundary surface of the container opening. In the assembled state of the closure system, the plug portion is fitted into the container opening, the cover portion abuts the boundary surface, and the cage member is mounted to the container. The cage member has a locking structure that in a detached position is disengaged from the container, and in a fixed position engages a corresponding structure of the container. The lock activation formation is configured to interact with the cage member such that the cage member changes from the detached position to the fixed position.

Medical bottle adapter

A syringe pack with a prefilled syringe () and a packaging () comprises: a barrel part () with an orifice () at a proximal end and a flange portion () at a distal end; a plunger part () extending through the distal end of the barrel part () into the barrel part (); a stopper () adjacent to a proximal end of the plunger part () and arranged inside the barrel part () such that a dosage chamber () is formed inside the barrel part (); and a drug substance arranged inside the dosage chamber (), wherein the prefilled syringe () is arranged in the packaging () and the packaging () is configured to allow external sterilization of the prefilled syringe () arranged in the packaging (). The packaging () comprises a containment part () having a fixing structure () which holds the barrel part () of the prefilled syringe () in a defined fix position; a constraining structure () which acts on the plunger part () of the prefilled syringe () to block a movement of the plunger part () of the prefilled syringe () in a distal direction; and a cover part () tightly closing the containment ().

Syringe pack and method of packing a prefilled syringe

A safety arrangement for being used in a medicament delivery device, comprising a container holder with a body section and a flange seat and a shell. The container holder is arranged to receive a container with a longitudinal body at one end passing over into a distal flange and at an opposite end passing over into a proximal orifice via a shoulder, such that the distal flanges of the container contacts the flange seat of the container holder. Moreover, the container holder is arranged in the shell such that the container holder is movable in a proximal direction in relation to the shell. A blocking element is arranged between the shell and the container holder. A blocking initiating structure is arranged to reposition the blocking element when the container holder is moved in the proximal direction in relation to the shell from a first position to a second position.

Safety arrangement and medical delivery device

Growing community of inventors

Basel, Switzerland

Neil Bentley Cammish