Merck Frosst Canada, Inc.

Merck Frosst Canada & Co.

Neil A Munday

Donald W Nicholson

John P Vaillancourt

Ambereen Ali

A complementary DNA (cDNA) encoding full length form of ICE.sub.rel -II is identified, sequenced and isolated. The cDNA is cloned into expression vectors for expression in recombinant hosts. The cDNA is useful to produce recombinant full length ICE.sub.rel -II. The cDNA and the recombinant ICE.sub.rel -II protein derived therefrom are useful in diagnostic kits, laboratory reagents and assays. The cDNA and the recombinant ICE.sub.rel -II protein may be used to identify compounds that affect ICE.sub.rel -II function, inflammation and cell apoptosis. ICE.sub.rel -II function, inflammation and cell apoptosis may also be modulated by ICE.sub.rel -II antisense or gene therapy.

DNA encoding precursor of interleukin-1.beta. converting enzyme--related

Interleukin-1.beta. converting enzyme-related cysteine proteinase II

DNA encoding precursor of interleukin-1.beta. converting enzyme-related

A complementary DNA (cDNA) encoding full length form of ICE.sub.rel -III is identified, sequenced and isolated. The cDNA is cloned into expression vectors for expression in recombinant hosts. The cDNA is useful to produce recombinant full length ICE.sub.rel -III. The cDNA and the recombinant ICE.sub.rel -III protein derived therefrom are useful in diagnostic kits, laboratory reagents and assays. The cDNA and the recombinant ICE.sub.rel -III protein may be used to identify compounds that affect ICE.sub.rel -III function, inflammation and cell apoptosis. ICE.sub.rel -III function, inflammation and cell apoptosis may also be modulated by ICE.sub.rel -III antisense or gene therapy.

DNA encoding precursor of interleukin-1 beta converting enzyme - related

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Guelph, Canada

Neil A Munday