Genzyme Corporation

Neha Shah

Jason Walther

Cheng Cheng

Timothy Allan Johnson

Jonathan Wang

Christopher Hwang

Seul-A Bae

Jiuyi Lu

Yukun Ren

Jean McLarty

Timothy Johnson

Provided herein are methods of culturing a mammalian cell in a liquid medium including poloxamer-188 at a concentration of 1.8 g/L or at a greater concentration than 1.8 g/L more or a liquid medium that includes a poloxamer-188 concentration that is selected based on one or more factors selected from the group of: pore size, pore type, gas flow rate, viable cell density in the medium, and markers related to cell stress.

Methods of culturing a mammalian cell

Provided herein are methods of predicting the effect of a concentration of a sensitizer on cell viability in a production bioreactor, methods of improving cell viability in a production bioreactor, methods of predicting cell viability in a production bioreactor, and methods for culturing a cell in a production bioreactor.

Methods for improving cell viability in a production bioreactor

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Bridgewater, NJ, United States of America

Neha Shah