Gilead Sciences, Inc.

Nmd Pharma A/s

Epitherapeutics Aps

Neerja Saraswat

Marc A Labelle

Thomas Boesen

Farman Ullah

Ramkrishna Reddy Vakiti

Ying Yang

Mukund Mehrotra

Lars J S Knutsen

Qasim Khan

Dastagiri Dudekula

Utpal Sharma

Marc Labelle

Thomas Holm Pedersen

Nicholas Kelly

Cyril Cook

Claus Elsborg Olesen

Martin E Cooper

Martin Brandhøj Skov

Rafiq A Taj

Anders Riisager

Paul Brian Little

Rui Zhang

Marc (deceased) Labelle

Martin Broch-Lips

Lars JS Knutsen

The present disclosure relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein can inhibit the CIC-1 ion channel.

Compounds for the treatment of neuromuscular disorders

The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit the CIC-1 ion channel. The compounds include phenoxy propanoic acid, phenoxy propanoate, and phenoxy butanoate compounds.

The present application relates to compounds being of Formula (I), (II), (III), (IV), (V), (VI), (IIIa), (IIIb), (IIIc), (IIId), (IIIe), (IIIf), and (IIIg). Compounds of Formula (I) have the structure: wherein Q, R, R, R, M, A and Y are as defined herein. The compounds of the application can modulate the activity of histone demethylases (HDMEs), and can be useful for the prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, e.g., cancer.

Compounds and methods for inhibiting histone demethylases

Compounds of the form In which Q is selected from &#x2014;CH&#x2550;NR, &#x2014;W, &#x2014;CHNHR, &#x2014;CH&#x2550;O and &#x2014;CH(OR)capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer and formulations and methods of use of such compounds.

Inhibitors of histone demethylases

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Winnipeg, Canada

Neerja Saraswat