Aventis Pharma S.a.

Roussel Uclaf

Hoechst Aktiengesellschaft

Sanofi-aventis

Neerja Bhatnagar

Jean Buendia

Christine Griffoul

Jean-Francois Gourvest

Adalbert Wagner

Jacques Mauger

Jean-Georges Teutsch

Andre Claussner

Jidong Zhang

Colette Colladant

Michele Resche Rigon

Christian Marchandeau

Holger Heitsch

Didier Babin

Jean-Marie Ruxer

Francis Brion

Pierre Broto

Didier Benard

Francois Brion

The invention relates to the preparation of substituted caprolactams, a method for the preparation thereof, compositions containing them and the use thereof as a medicament, particularly as anticancer agents.

Bengamides with a substituted caprolactam cycle, method for the preparation thereof, compositions containing them and use thereof

The invention relates particularly to 2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof as a medicament, particularly as anti-cancer agents.

2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof

The present invention discloses and claims hexahydropyridazine-3-carboxylic acid hydrazides and hydrazones of formula (I) as inhibitors of proteases and kinases, and methods of using said compounds of formula (I) for the prevention or treatment of certain cardiovascular, central nervous system, inflammatory, and bone diseases as well as infectious diseases and certain cancers. Combinatorial libraries of the compounds of formula (I), pharmaceutical compositions, and methods for the preparation of combinatorial libraries and the compounds of formula (I) are also disclosed and claimed.

Hexahydropyridazine-3-carboxylic acid hydrazide and hydrazone derivatives, combinatorial libraries containing same, pharmaceutical compositions containing same and methods of preparation

The invention relates to a pyridazine derivative of formula (I), wherein the variables are as defined herein, pharmaceutical composition thereof, process for its preparation, and its pharmaceutical use.

Pyridazine derivative, pharmaceutical composition thereof, its pharmaceutical use, and process for its preparation

The present invention discloses and claims compounds of formula (I)as inhibitors of proteases and kinases, method using said compounds of formula (I) for the prevention or treatment of certain cardiovascular, central nervous system, inflammatory, and bone diseases as well as infectious diseases and certain cancers. Combinatorial libraries of compounds of formula (I), pharmaceutical compositions and methods for preparation of combinatorial libraries and compounds of formula (I) are also disclosed and claimed.

Hexahydropyridazine-3-carboxylic acid derivatives, pharmaceutical compositions containing same and methods of preparation

Steroids, their use as medicaments, their preparation process, the intermediates of this process and the compositions containing them

The subject of the invention is the products of formula (I):

Pregnane derivatives with no alpha-17 substitutent, their medicinal use, manufacturing method and its intermediaries and related compounds

The invention relates to a process for the preparation of a compound of the formula (I) ##STR1## in which X is an optionally protected formyl group and

Process for the preparation of biphenyl derivatives

Biphenyl derivatives and processes for the preparation of biphenyl derivatives are described. A compound of formula (I) is disclosed ##STR1## in which the substituent X is --CHO or --CH(OR.sup.1)OR.sup.2, where R.sup.1 and R.sup.2 independently of one another are (C.sub.1 -C.sub.6)-alkyl or R.sup.1 and R.sup.2 together are an alkylene group (--CH.sub.2).sub.n --, where n is 2, 3 4 or 5 and R is --F, --Cl, --NO.sub.2, --(CH.sub.2).sub.m --COOR.sup.3, --(CH.sub.2).sub.m --CONHR.sup.3, --(CH.sub.2).sub.m --CN, --SO.sub.2 NH--COOR.sup.3, --SO.sub.2 NH--CO--NHR.sup.3, --SO.sub.2 NH--SO.sub.2 --R.sup.3, --NHSO.sub.2 R.sup.3, ##STR2## --PO.sub.3 R.sup.3, --NH--SO.sub.2 --CF.sub.3, --SO.sub.2 NR.sup.4 where R.sup.3 is hydrogen, (C.sub.1 -C.sub.6)-alkyl, (C.sub.3 -C.sub.6)cycloalkyl, or (C.sub.1 -C.sub.6)-alkyl-(C.sub.3 -C.sub.6)cycloalkyl and R.sup.4 is a group .dbd.C--N(CH.sub.3).sub.2, and m is 0, 1, 2, 3, or 4. The invention also relates to a process for the preparation of a compound of the formula (I) in which X is an optionally protected formyl group and R is a group which is itself inert to the reaction conditions of the synthesis, which comprises reacting a compound of the formula (II) ##STR3## with a substituted phenyl-halogen compound of the formula (III) ##STR4## wherein the substituent Hal is a halogen group.

A novel process for the preparation of a compound of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the text.

Process for the preparation of

The novel process of the invention for the preparation of a compound of the formula ##STR1##

Process

A novel process for the preparation of a compound of the formula ##STR1##

Process for the preparation of biphenyl-imidazole derivatives

A novel process for the preparation of isomers or mixtures of isomers of compounds of the formula ##STR1## and novel intermediates therefore.

Process and intermediates

A process for preparation of a compound of the formula ##STR1##

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Savigny sur Orge, France

Neerja Bhatnagar